Two papers, one in Nature (Jones et al., 2006) and the other in the Journal of Clinical Investigation (Verma et al., 2006) show that Nck adaptor proteins connect phosphorylated nephrin with actin polymerization in podocyte foot processes, structures important for slit-diaphragm formation in the kidney. Their results further our understanding of podocyte development and repair in glomerular disease
Background. Proteinuria, one of the main manifestations of nephrotic syndrome, is an important risk ...
Proteinuric kidney diseases are a group of disorders with diverse pathological mechanisms associated...
Nephrin localizes to the slit pore of the glomerular epithelial cellBackgroundRecognition that mutat...
Two papers, one in Nature (Jones et al., 2006) and the other in the Journal of Clinical Investigatio...
Regulation and maintenance of the actin cytoskeleton of podocytes has emerged as a critical process ...
Podocytes are terminally differentiated and structurally unique cells having interdigitating foot pr...
Podocytes are a major component of the glomerular blood filtration barrier, and alterations to the m...
The actin cytoskeleton is critical to the proper function of cells and its misregulation can lead to...
Uchida et al. show in this issue that in rat and human nephrosis, tyrosine phosphorylation of nephri...
Background/Aims: The transmembrane proteins Neph1 and nephrin form a complex in the slit diaphragm (...
Podocytes are highly differentiated epithelial cells that contribute to the selective filtration bar...
Nephrin is expressed at the basolateral aspect of podocytes and is an important signaling protein at...
Nephrin is a slit diaphragm protein critical for structural and functional integrity of visceral glo...
Nephrin, a structural molecule, is also a signaling molecule after phosphorylation. Inhibition of ne...
Glomerular podocytes are highly specialized cells with a complex cytoarchitecture. Their most promin...
Background. Proteinuria, one of the main manifestations of nephrotic syndrome, is an important risk ...
Proteinuric kidney diseases are a group of disorders with diverse pathological mechanisms associated...
Nephrin localizes to the slit pore of the glomerular epithelial cellBackgroundRecognition that mutat...
Two papers, one in Nature (Jones et al., 2006) and the other in the Journal of Clinical Investigatio...
Regulation and maintenance of the actin cytoskeleton of podocytes has emerged as a critical process ...
Podocytes are terminally differentiated and structurally unique cells having interdigitating foot pr...
Podocytes are a major component of the glomerular blood filtration barrier, and alterations to the m...
The actin cytoskeleton is critical to the proper function of cells and its misregulation can lead to...
Uchida et al. show in this issue that in rat and human nephrosis, tyrosine phosphorylation of nephri...
Background/Aims: The transmembrane proteins Neph1 and nephrin form a complex in the slit diaphragm (...
Podocytes are highly differentiated epithelial cells that contribute to the selective filtration bar...
Nephrin is expressed at the basolateral aspect of podocytes and is an important signaling protein at...
Nephrin is a slit diaphragm protein critical for structural and functional integrity of visceral glo...
Nephrin, a structural molecule, is also a signaling molecule after phosphorylation. Inhibition of ne...
Glomerular podocytes are highly specialized cells with a complex cytoarchitecture. Their most promin...
Background. Proteinuria, one of the main manifestations of nephrotic syndrome, is an important risk ...
Proteinuric kidney diseases are a group of disorders with diverse pathological mechanisms associated...
Nephrin localizes to the slit pore of the glomerular epithelial cellBackgroundRecognition that mutat...