In this issue of Neuron, Shen et al. (2015) demonstrate that the M4 muscarinic receptor regulates striatal plasticity. The authors use an M4-positive allosteric modulator, which facilitates long-term depression in direct pathway neurons and reverses aberrant plasticity in levodopa-induced dyskinesia
Muscarinic receptors type 4 are one of the five subtypes of muscarinic receptors, that are members o...
International audienceOver the last decade, striatal cholinergic interneurons (ChIs) have reemerged ...
Long- and short-term changes in the efficacy of synaptic transmission are known as synaptic plastici...
SummaryA balanced interaction between dopaminergic and cholinergic signaling in the striatum is crit...
A balanced interaction between dopaminergic and cholinergic signaling in the striatum is critical to...
In this issue of Neuron, Shen et al. (2015) demonstrate that the M4 muscarinic receptor regulates st...
International audienceThe opposing action of dopamine and acetylcholine has long been known to play ...
Cognitive flexibility is an important mechanism enabling organisms to adapt to their changing enviro...
Broad-spectrum muscarinic receptor antagonists have represented the first available treatment for di...
Muscarinic autoreceptors regulate cholinergic tone in the striatum. We investigated the functional c...
In early-onset generalized torsion dystonia, caused by a GAG deletion in TOR1A (DYT1), enhanced stri...
International audienceOver the last decade, striatal cholinergic interneurons (ChIs) have reemerged ...
The basal ganglia are a network of subcortical brain nuclei important for action selection and motor...
International audienceOver the last decade, striatal cholinergic interneurons (ChIs) have reemerged ...
SummaryPlasticity of excitatory synapses onto striatal projection neurons (MSNs) has the potential t...
Muscarinic receptors type 4 are one of the five subtypes of muscarinic receptors, that are members o...
International audienceOver the last decade, striatal cholinergic interneurons (ChIs) have reemerged ...
Long- and short-term changes in the efficacy of synaptic transmission are known as synaptic plastici...
SummaryA balanced interaction between dopaminergic and cholinergic signaling in the striatum is crit...
A balanced interaction between dopaminergic and cholinergic signaling in the striatum is critical to...
In this issue of Neuron, Shen et al. (2015) demonstrate that the M4 muscarinic receptor regulates st...
International audienceThe opposing action of dopamine and acetylcholine has long been known to play ...
Cognitive flexibility is an important mechanism enabling organisms to adapt to their changing enviro...
Broad-spectrum muscarinic receptor antagonists have represented the first available treatment for di...
Muscarinic autoreceptors regulate cholinergic tone in the striatum. We investigated the functional c...
In early-onset generalized torsion dystonia, caused by a GAG deletion in TOR1A (DYT1), enhanced stri...
International audienceOver the last decade, striatal cholinergic interneurons (ChIs) have reemerged ...
The basal ganglia are a network of subcortical brain nuclei important for action selection and motor...
International audienceOver the last decade, striatal cholinergic interneurons (ChIs) have reemerged ...
SummaryPlasticity of excitatory synapses onto striatal projection neurons (MSNs) has the potential t...
Muscarinic receptors type 4 are one of the five subtypes of muscarinic receptors, that are members o...
International audienceOver the last decade, striatal cholinergic interneurons (ChIs) have reemerged ...
Long- and short-term changes in the efficacy of synaptic transmission are known as synaptic plastici...
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