AbstractAdipocyte differentiation is controlled by a tightly regulated transcriptional cascade in which PPARγ and members of the C/EBP family are key players. Here we review the roles of PPARγ and C/EBPs in adipocyte differentiation with emphasis on the recently published genome-wide binding profiles for PPARγ and C/EBPα. Interestingly, these analyses show that PPARγ and C/EBPα binding sites are associated with most genes that are induced during adipogenesis suggesting direct activation of many more adipocyte genes than previously anticipated. Furthermore, an extensive overlap between the C/EBPα and PPARγ cistromes indicate a hitherto unrecognized direct crosstalk between these transcription factors. As more genome-wide data emerge in the f...
International audienceThe nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ) ...
pressed adipocyte differentiation, partially through direct binding to the peroxisome proliferator-a...
The nuclear receptor PPAR γ is a key regulator of adipogenesis, and alterations of its function are ...
AbstractAdipocyte differentiation is controlled by a tightly regulated transcriptional cascade in wh...
The epidemics of obesity and metabolic disease have increased interest in adipose tissue as a potent...
Major insights into the understanding of the molecular regulation of adipocyte diVerentiation have s...
Treatment of 3T3-L1 preadipocytes with differentiation inducers triggers a cascade in which C/EBPβ i...
<div><p>Adipose tissue renewal and obesity-driven expansion of fat cell number are dependent on prol...
Adipose tissue renewal and obesity-driven expansion of fat cell number are dependent on proliferatio...
International audienceThe nuclear receptor peroxisome proliferator-activated receptor (PPAR) is a tr...
<div><p>Differentiation signaling results in reprogramming of cellular gene expression that leads to...
Adipocytes are the defining cell type of adipose tissue. Once considered a passive participant in en...
The nuclear receptor PPARγ is a key regulator of adipogenesis, and alterations of its function are a...
Peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-dependent transcription factor ...
pressed adipocyte differentiation, partially through direct binding to the peroxisome proliferator-a...
International audienceThe nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ) ...
pressed adipocyte differentiation, partially through direct binding to the peroxisome proliferator-a...
The nuclear receptor PPAR γ is a key regulator of adipogenesis, and alterations of its function are ...
AbstractAdipocyte differentiation is controlled by a tightly regulated transcriptional cascade in wh...
The epidemics of obesity and metabolic disease have increased interest in adipose tissue as a potent...
Major insights into the understanding of the molecular regulation of adipocyte diVerentiation have s...
Treatment of 3T3-L1 preadipocytes with differentiation inducers triggers a cascade in which C/EBPβ i...
<div><p>Adipose tissue renewal and obesity-driven expansion of fat cell number are dependent on prol...
Adipose tissue renewal and obesity-driven expansion of fat cell number are dependent on proliferatio...
International audienceThe nuclear receptor peroxisome proliferator-activated receptor (PPAR) is a tr...
<div><p>Differentiation signaling results in reprogramming of cellular gene expression that leads to...
Adipocytes are the defining cell type of adipose tissue. Once considered a passive participant in en...
The nuclear receptor PPARγ is a key regulator of adipogenesis, and alterations of its function are a...
Peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-dependent transcription factor ...
pressed adipocyte differentiation, partially through direct binding to the peroxisome proliferator-a...
International audienceThe nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ) ...
pressed adipocyte differentiation, partially through direct binding to the peroxisome proliferator-a...
The nuclear receptor PPAR γ is a key regulator of adipogenesis, and alterations of its function are ...