New potentiometric sensors based on two competitive recognition sites for determining tetracycline residues using flow-through system

AbstractNew potentiometric membrane sensors for tetracycline (TC) are described based on the use of a newly designed molecularly imprinted polymer (MIP) material based on 2-vinylpyridine as a functional monomer, AmION (I) [Calix-4-arene tetraacetic acid ester] as neutral ionophore in plasticized PVC membranes. Effects of lipophilic salts and various foreign common ions are tested. The sensors exhibit significantly high sensitivity, stability and selectivity for TC+ ions over many common ions and are successfully used for determining TC+ ions in spiked biological fluid samples under static and hydrodynamic mode of operations