Angiostatin prevents IL-1β-induced down-regulation of eNOS expression by inhibiting the NF-κB cascade
- Kawasaki, Yasushi
- Yokobayashi, Eriko
- Sakamoto, Kentaro
- Tenma, Eri
- Takaki, Haruka
- Chiba, Yuki
- Otashiro, Tomomi
- Ishihara, Mai
- Yonezawa, Sei
- Sugiyama, Akinori
- Natori, Yasuhiro
Publication date
November 2015
DOI Publisher
The Authors. Production and hosting by Elsevier B.V.Abstract
AbstractThis study aimed to elucidate the protective potential of angiostatin in inflamed endothelial cells in culture. We assessed the effect of angiostatin on the expression of ICAM-1 and eNOS. Angiostatin prevented IL-1β-induced down-regulation of eNOS expression, but produced no significant changes on IL-1β-induced up-regulation of ICAM-1. We then explored the effect of angiostatin on IL-1β-mediated inflammatory signaling and found that angiostatin inhibited IL-1β-mediated nuclear translocation of NF-κB. Thus, our results suggest that angiostatin prevents IL-1β-induced down-regulation of eNOS expression via inhibition of the NF-κB cascade; this may be the anti-inflammatory mechanism of angiostatin
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