A Study of Noncovalent Protein Complexes by Matrix-Assisted Laser Desorption/Ionization
- Song, Fenhong
Publication date
July 2007
DOI Publisher
American Society for Mass Spectrometry. Published by Elsevier B.V.Abstract
A sample preparation method has been developed for detection of noncovalent protein–protein complexes by MALDI in this work. An aqueous solution of the matrix at pH 7 allows the reproducible detection of a protein dimer, a protein tetramer, and a heterodimer. The signals are stable under long irradiation and can be detected at wide ranges of concentrations and with different laser intensities
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