SummaryObjectiveThe development of chondrocytic cell lines has enabled the investigation of the role of cellular phenotype and mechanisms in articular cartilage biology and physiopathology of several rheumatic diseases. Among them, the T/C-28a2 cell line has become a common tool in cartilage research. Recent results from our group have revealed that primary human chondrocytes in tissue and in monolayer culture contain high levels of connexin 43 (Cx43) and are able to directly communicate through gap junction (GJ) channels. These results challenge the existing thesis of cartilage physiology, that chondrocytes do not have the capacity to physically communicate with each other. Established cell lines offer the advantage of convenience and unif...
Normal cell physiological processes rely heavily on cues from the extracellular environment to coord...
Chondrocytes are the uniquely resident cells found in all types of cartilage and key to their functi...
Osteoarthritis (OA) is the most common joint disease. In the last years, the research community has ...
SummaryObjectiveThe development of chondrocytic cell lines has enabled the investigation of the role...
Osteoarthritis (OA) is the most common joint disease and involves progressive degeneration of articu...
Objective This study investigated whether chondrocytes within the cartilage matrix have the capacity...
Gap junctional intercellular communication has been demonstrated in bone cells and may contribute to...
Chondrocytes are the uniquely resident cells found in all types of cartilage and key to their functi...
Gap junctions (GJs) formed by connexins (Cxs) play an important role in the intercellular communicat...
Abstract. Articular cartilage is a tissue designed to withstand compression during joint movement an...
Osteoarthritis (OA), a chronic disease characterized by articular cartilage degeneration, is a leadi...
Gap Junctions are membrane channels that allow direct intracellular transfer of ions and small molec...
International audienceAlthough it has been demonstrated that human bone marrow stromal cells (hBMSCs...
AbstractGap junctional intercellular communication (GJIC) mediated by connexins, in particular conne...
OBJECTIVE: To identify markers associated with the chondrogenic capacity of expanded human articular...
Normal cell physiological processes rely heavily on cues from the extracellular environment to coord...
Chondrocytes are the uniquely resident cells found in all types of cartilage and key to their functi...
Osteoarthritis (OA) is the most common joint disease. In the last years, the research community has ...
SummaryObjectiveThe development of chondrocytic cell lines has enabled the investigation of the role...
Osteoarthritis (OA) is the most common joint disease and involves progressive degeneration of articu...
Objective This study investigated whether chondrocytes within the cartilage matrix have the capacity...
Gap junctional intercellular communication has been demonstrated in bone cells and may contribute to...
Chondrocytes are the uniquely resident cells found in all types of cartilage and key to their functi...
Gap junctions (GJs) formed by connexins (Cxs) play an important role in the intercellular communicat...
Abstract. Articular cartilage is a tissue designed to withstand compression during joint movement an...
Osteoarthritis (OA), a chronic disease characterized by articular cartilage degeneration, is a leadi...
Gap Junctions are membrane channels that allow direct intracellular transfer of ions and small molec...
International audienceAlthough it has been demonstrated that human bone marrow stromal cells (hBMSCs...
AbstractGap junctional intercellular communication (GJIC) mediated by connexins, in particular conne...
OBJECTIVE: To identify markers associated with the chondrogenic capacity of expanded human articular...
Normal cell physiological processes rely heavily on cues from the extracellular environment to coord...
Chondrocytes are the uniquely resident cells found in all types of cartilage and key to their functi...
Osteoarthritis (OA) is the most common joint disease. In the last years, the research community has ...