Presence of CAKUT: A predictor of difficult-to-control nephrotic syndrome

SummaryNephrotic syndrome and congenital anomalies of the kidney and urinary tract are independent causes of renal dysfunction in children. The simultaneous occurrence of these infrequent conditions is rarely reported. Whether the occurrence of one influences the outcome of the other is also not known. Defects of specific genes have been hypothesized for the occurrence of a few of these anomalies. It is possible that yet-to-be-identified genetic defects are contributing to both of these conditions in specific individuals. We report a series of 10 patients with congenital anomalies of the kidney and urinary tract and nephrotic syndrome that had a difficult course