Tumor cells frequently display an abnormal number of chromosomes, a phenomenon known as aneuploidy. Tang et al. (2011) now show that aneuploid cells are particularly sensitive to compounds that induce proteotoxic and energy stress. Could this vulnerability lead to new cancer therapies
Although nearly ubiquitous in cancer, aneuploidy exerts detrimental effects on human cells. We recen...
Tetraploidy is an aneuploidy-permissive condition that can fuel tumorgenesis. The tip-over hypothesi...
Aneuploidy, defined as whole chromosome gains and losses, is associated with poor patient prognosis ...
Aneuploidy is a characteristic of cancer, with greater than 90% of all solid tumors in humans carryi...
SummaryAneuploidy, an incorrect chromosome number, is a hallmark of cancer. Compounds that cause let...
Selective targeting of aneuploid cells is an attractive strategy for cancer treatment(1). However, i...
Aneuploidy is a ubiquitous feature of human tumors, but the acquisition of aneuploidy typically anta...
Chromosomal instability is the process of mis-segregation for ongoing chromosomes, which leads to ce...
Aneuploidy is a very rare and tissue-specific event in normal conditions, occurring in a low number ...
The role of aneuploidy in tumorigenesis remains poorly understood, although the two have been known ...
SummaryAn abnormal chromosome number, aneuploidy, is a common characteristic of tumor cells. Boveri ...
Aneuploidy refers to karyotypic abnormalities characterized by gain or loss of individual chromosome...
Aneuploidy, described as an abnormal number of whole chromosomes or parts of them, has been observed...
When cells mis-segregate chromosomes during cell division, this can lead to cells having an abnormal...
Abnormal chromosome content - also known as aneuploidy - is the most common characteristic of human ...
Although nearly ubiquitous in cancer, aneuploidy exerts detrimental effects on human cells. We recen...
Tetraploidy is an aneuploidy-permissive condition that can fuel tumorgenesis. The tip-over hypothesi...
Aneuploidy, defined as whole chromosome gains and losses, is associated with poor patient prognosis ...
Aneuploidy is a characteristic of cancer, with greater than 90% of all solid tumors in humans carryi...
SummaryAneuploidy, an incorrect chromosome number, is a hallmark of cancer. Compounds that cause let...
Selective targeting of aneuploid cells is an attractive strategy for cancer treatment(1). However, i...
Aneuploidy is a ubiquitous feature of human tumors, but the acquisition of aneuploidy typically anta...
Chromosomal instability is the process of mis-segregation for ongoing chromosomes, which leads to ce...
Aneuploidy is a very rare and tissue-specific event in normal conditions, occurring in a low number ...
The role of aneuploidy in tumorigenesis remains poorly understood, although the two have been known ...
SummaryAn abnormal chromosome number, aneuploidy, is a common characteristic of tumor cells. Boveri ...
Aneuploidy refers to karyotypic abnormalities characterized by gain or loss of individual chromosome...
Aneuploidy, described as an abnormal number of whole chromosomes or parts of them, has been observed...
When cells mis-segregate chromosomes during cell division, this can lead to cells having an abnormal...
Abnormal chromosome content - also known as aneuploidy - is the most common characteristic of human ...
Although nearly ubiquitous in cancer, aneuploidy exerts detrimental effects on human cells. We recen...
Tetraploidy is an aneuploidy-permissive condition that can fuel tumorgenesis. The tip-over hypothesi...
Aneuploidy, defined as whole chromosome gains and losses, is associated with poor patient prognosis ...
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