AbstractMacrophages responding to viral infections may contribute to autoimmune demyelinating diseases (ADD). Macrophages from ADD-susceptible SJL/J mice responding to Theiler's Virus (TMEV) infection, the TLR7 agonist loxoribine, or the TLR4 agonist-LPS expressed less IL-12 p35 but more IL-12/23 p40 and IFN-β than macrophages from ADD-resistant B10.S mice. While expression of IRF-1 and -7 was similar between B10.S and SJL/J TMEV-infected macrophages, SJL/J but not B10.S macrophages exhibited constitutively active IRF-3. In contrast to overexpressed IRF-1, IRF-5, and IRF-7, which stimulated p35 promoter reporter activity, overexpressed IRF-3 repressed p35 promoter activity in response to TMEV infection, loxoribine, IFN-γ/LPS, but not IFN-γ ...
Abstract Background Theiler’s virus infection induces chronic demyelinating disease in mice and has ...
Environmental factors such as invading pathogens modify the microenvironment of the host. Since the ...
Environmental factors such as invading pathogens modify the microenvironment of the host. Since the ...
AbstractMacrophages responding to viral infections may contribute to autoimmune demyelinating diseas...
AbstractPersistent viral infections can lead to disease such as myocarditis. Theiler's murine enceph...
Interleukin-33 (IL-33), which promotes M2 macrophage development, may influence the control of virus...
Interleukin-33 (IL-33), which promotes M2 macrophage development, may influence the control of virus...
AbstractPersistent viral infections can lead to disease such as myocarditis. Theiler's murine enceph...
Interleukin-33 (IL-33), which promotes M2 macrophage development, may influence the control of virus...
Interleukin-33 (IL-33), which promotes M2 macrophage development, may influence the control of virus...
AbstractIntracranial inoculation of susceptible SJL mice with Theiler's murine encephalomyelitis vir...
Background: We have previously shown that toll-like receptor 3 (TLR3)-mediated signaling plays an im...
Intracerebral infection with Theiler’s murine encephalomyelitis virus (TMEV) induces immune-mediated...
The role of chemokines during some viral infections is unpredictable because the inflammatory respon...
Infection of various cells with Theiler's murine encephalomyelitis virus (TMEV) activates the TLR- a...
Abstract Background Theiler’s virus infection induces chronic demyelinating disease in mice and has ...
Environmental factors such as invading pathogens modify the microenvironment of the host. Since the ...
Environmental factors such as invading pathogens modify the microenvironment of the host. Since the ...
AbstractMacrophages responding to viral infections may contribute to autoimmune demyelinating diseas...
AbstractPersistent viral infections can lead to disease such as myocarditis. Theiler's murine enceph...
Interleukin-33 (IL-33), which promotes M2 macrophage development, may influence the control of virus...
Interleukin-33 (IL-33), which promotes M2 macrophage development, may influence the control of virus...
AbstractPersistent viral infections can lead to disease such as myocarditis. Theiler's murine enceph...
Interleukin-33 (IL-33), which promotes M2 macrophage development, may influence the control of virus...
Interleukin-33 (IL-33), which promotes M2 macrophage development, may influence the control of virus...
AbstractIntracranial inoculation of susceptible SJL mice with Theiler's murine encephalomyelitis vir...
Background: We have previously shown that toll-like receptor 3 (TLR3)-mediated signaling plays an im...
Intracerebral infection with Theiler’s murine encephalomyelitis virus (TMEV) induces immune-mediated...
The role of chemokines during some viral infections is unpredictable because the inflammatory respon...
Infection of various cells with Theiler's murine encephalomyelitis virus (TMEV) activates the TLR- a...
Abstract Background Theiler’s virus infection induces chronic demyelinating disease in mice and has ...
Environmental factors such as invading pathogens modify the microenvironment of the host. Since the ...
Environmental factors such as invading pathogens modify the microenvironment of the host. Since the ...