AbstractBackground: Roundabout (Robo) receptors and their ligand Slit are important regulators of axon guidance and cell migration. The development of Drosophila embryonic sense organs provides a neuronal migration paradigm where the in vivo roles of Slit and Robo can be assayed using genetics.Results: Here we show that Slit-Robo signaling controls migration of Drosophila larval sensory neurons that are part of the Chordotonal (Cho) stretch receptor organs. We used live imaging to show that abdominal Cho organs normally migrate ventrally during development, whereas thoracic Cho organs do not. Robo2 overexpression in cis (in the sensory neurons) or in trans (on neighboring visceral mesoderm) transforms abdominal organs to a thoracic morpholo...
During development, neurons extend axons which follow highly stereotypic pathways to form a template...
The axonal wiring molecule Slit and its Round-About (Robo) receptors are conserved regulators of ner...
The Roundabout (Robo) receptors have been intensively studied for their role in regulating axon guid...
Background: Roundabout (Robo) receptors and their ligand Slit are important regulators of axon guida...
AbstractBackground: Roundabout (Robo) receptors and their ligand Slit are important regulators of ax...
International audienceNeurogenesis is achieved through a sequence of steps that include specificatio...
Maintenance of bilateral symmetry throughout animal development requires that both left and right ha...
AbstractPrevious studies showed that Roundabout (Robo) in Drosophila is a repulsive axon guidance re...
Previous studies showed that Roundabout (Robo) in Drosophila is a repulsive axon guidance receptor t...
Space-filling neurons extensively sample their receptive fields with fine dendritic branches. In thi...
Sensory information relayed to the brain is dependent on complex, yet precise spatial organization o...
AbstractSpace-filling neurons extensively sample their receptive fields with fine dendritic branches...
AbstractThe robo gene in Drosophila was identified in a large-scale mutant screen for genes that con...
SummaryThe orthogonal array of axon pathways in the Drosophila CNS is constructed in part under the ...
SummaryTranscription factors establish neural diversity and wiring specificity; however, how they or...
During development, neurons extend axons which follow highly stereotypic pathways to form a template...
The axonal wiring molecule Slit and its Round-About (Robo) receptors are conserved regulators of ner...
The Roundabout (Robo) receptors have been intensively studied for their role in regulating axon guid...
Background: Roundabout (Robo) receptors and their ligand Slit are important regulators of axon guida...
AbstractBackground: Roundabout (Robo) receptors and their ligand Slit are important regulators of ax...
International audienceNeurogenesis is achieved through a sequence of steps that include specificatio...
Maintenance of bilateral symmetry throughout animal development requires that both left and right ha...
AbstractPrevious studies showed that Roundabout (Robo) in Drosophila is a repulsive axon guidance re...
Previous studies showed that Roundabout (Robo) in Drosophila is a repulsive axon guidance receptor t...
Space-filling neurons extensively sample their receptive fields with fine dendritic branches. In thi...
Sensory information relayed to the brain is dependent on complex, yet precise spatial organization o...
AbstractSpace-filling neurons extensively sample their receptive fields with fine dendritic branches...
AbstractThe robo gene in Drosophila was identified in a large-scale mutant screen for genes that con...
SummaryThe orthogonal array of axon pathways in the Drosophila CNS is constructed in part under the ...
SummaryTranscription factors establish neural diversity and wiring specificity; however, how they or...
During development, neurons extend axons which follow highly stereotypic pathways to form a template...
The axonal wiring molecule Slit and its Round-About (Robo) receptors are conserved regulators of ner...
The Roundabout (Robo) receptors have been intensively studied for their role in regulating axon guid...