Paraneoplastic pemphigus (PNP) shows autoantibodies mainly to plakin and desmosomal cadherin family proteins. We have recently identified alpha-2-macroglobulin-like-1 (A2ML1), a broad range protease inhibitor, as a unique PNP antigen. In this study, we tested a large number of PNP sera by various methods. Forty (69.0%) of 58 PNP sera recognized A2ML1 recombinant protein expressed in COS7 cells by immunofluorescence (IF) and/or immunoprecipitation (IP)/immunoblotting (IB). IP/IB showed higher sensitivity than IF. In addition, 22 (37.9%) PNP sera reacted with A2ML1 by IB of cultured normal human keratinocytes (NHKs) under non-reducing conditions. Statistical analyses using various clinical and immunological data showed that the presence of an...
We Investigated the antigen molecules for six clinically typical cases of paraneoplastic pemphigus (...
Introduction: In paraneoplastic pemphigus (PNP), indirect immunofluorescence microscopy using rat bl...
We recently reported the production of a human monoclonal antibody (MoAb) derived from a patient wit...
Paraneoplastic pemphigus (PNP) shows autoantibodies mainly to plakin and desmosomal cadherin family ...
Paraneoplastic pemphigus (PNP) is a devastating autoimmune blistering disease, involving mucocutaneo...
BACKGROUND: Paraneoplastic pemphigus (PNP) is a devastating autoimmune blistering disease, involving...
Paraneoplastic pemphigus (PNP) is a devastating autoimmune blistering disease, involving mucocutaneo...
Paraneoplastic pemphigus (PNP) is an autoimmune blistering disease that occurs in association with u...
BACKGROUND Paraneoplastic pemphigus (PNP) is a devastating autoimmune multiorgan syndrome associa...
Paraneoplastic pemphigus (PNP) is a rare but severe multiorgan autoimmune disease that occurs in the...
Background The presence of autoantibodies against multiple epidermal proteins is an important featur...
Paraneoplastic pemphigus patients (PNP) develop a group of autoantibodies, among which those against...
P>Background Paraneoplastic pemphigus (PNP) is a malignancy-associated autoimmune disease in which c...
BackgroundParaneoplastic pemphigus (PNP) is a multiorgan disease characterized by antibodies against...
Recently, a previously unrecognized autoantibody mediated blistering disease, paraneoplastic pemphig...
We Investigated the antigen molecules for six clinically typical cases of paraneoplastic pemphigus (...
Introduction: In paraneoplastic pemphigus (PNP), indirect immunofluorescence microscopy using rat bl...
We recently reported the production of a human monoclonal antibody (MoAb) derived from a patient wit...
Paraneoplastic pemphigus (PNP) shows autoantibodies mainly to plakin and desmosomal cadherin family ...
Paraneoplastic pemphigus (PNP) is a devastating autoimmune blistering disease, involving mucocutaneo...
BACKGROUND: Paraneoplastic pemphigus (PNP) is a devastating autoimmune blistering disease, involving...
Paraneoplastic pemphigus (PNP) is a devastating autoimmune blistering disease, involving mucocutaneo...
Paraneoplastic pemphigus (PNP) is an autoimmune blistering disease that occurs in association with u...
BACKGROUND Paraneoplastic pemphigus (PNP) is a devastating autoimmune multiorgan syndrome associa...
Paraneoplastic pemphigus (PNP) is a rare but severe multiorgan autoimmune disease that occurs in the...
Background The presence of autoantibodies against multiple epidermal proteins is an important featur...
Paraneoplastic pemphigus patients (PNP) develop a group of autoantibodies, among which those against...
P>Background Paraneoplastic pemphigus (PNP) is a malignancy-associated autoimmune disease in which c...
BackgroundParaneoplastic pemphigus (PNP) is a multiorgan disease characterized by antibodies against...
Recently, a previously unrecognized autoantibody mediated blistering disease, paraneoplastic pemphig...
We Investigated the antigen molecules for six clinically typical cases of paraneoplastic pemphigus (...
Introduction: In paraneoplastic pemphigus (PNP), indirect immunofluorescence microscopy using rat bl...
We recently reported the production of a human monoclonal antibody (MoAb) derived from a patient wit...