Generation of iPSC lines from primary human amniotic fluid cells
- Drews, Katharina
- Matz, Peggy
- Adjaye, James
Publication date
November 2015
DOI Publisher
The Authors. Published by Elsevier B.V.Abstract
AbstractBy means of retroviral transduction using the four Yamanaka-factors OCT4, SOX2, KLF4 and c-MYC primary human amniotic fluid cells (AFCs) were reprogrammed into several iPSC lines. Pluripotency was confirmed both in vitro and in vivo. A comparative transcriptome analysis of the AF-derived iPSC line 41 and the human embryonic stem cell lines (H1 and H9) revealed a Pearson correlation of 0.953 and 0.941 respectively
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