Tyrosine phosphorylation controls many cellular functions. Yet the three-part toolkit that regulates phosphotyrosine signaling—tyrosine kinases, phosphotyrosine phosphatases, and Src Homology 2 (SH2) domains—is a relatively new innovation. Genomic analyses reveal how this revolutionary signaling system may have originated and why it rapidly became critical to metazoans
SH2 domains are long known prominent players in the field of phosphotyrosine recognition within sign...
SH2 domains are long known prominent players in the field of phosphotyrosine recognition within sign...
Phosphotyrosine (pY) signaling is instrumental to numerous cellular processes. pY recognition occurs...
Tyrosine phosphorylation controls many cellular functions. Yet the three-part toolkit that regulates...
Phosphotyrosine (pTyr) signaling, which plays a central role in cell-cell and cell-environment inter...
AbstractOver the last two decades, a new and unifying concept of cellular organization has emerged i...
The evolution of multicellular animals (i.e., metazoans) from a unicellular ancestor is one of the m...
AbstractTyrosine phosphorylation is an essential element of signal transduction in multicellular ani...
Phosphotyrosine (pTyr) signaling, which plays a central role in cell-cell and cell-environment inter...
In 1986, Pawson's group recognized a region of homology between two oncogenic tyrosine kinases that ...
International audiencePhosphotyrosine (pTyr) signaling has evolved into a key cell-to-cell communica...
Src Homology 2 (SH2) domain-containing proteins are critical for mediating cellular signaling from r...
SH2 domains are integral to many animal signaling pathways. By interacting with specific phosphotyro...
In order for cells to respond to their environment, a series of regulated molecular events has to ta...
Multicellular animals use a three-part molecular toolkit to mediate phospho-tyrosine signaling: Tyro...
SH2 domains are long known prominent players in the field of phosphotyrosine recognition within sign...
SH2 domains are long known prominent players in the field of phosphotyrosine recognition within sign...
Phosphotyrosine (pY) signaling is instrumental to numerous cellular processes. pY recognition occurs...
Tyrosine phosphorylation controls many cellular functions. Yet the three-part toolkit that regulates...
Phosphotyrosine (pTyr) signaling, which plays a central role in cell-cell and cell-environment inter...
AbstractOver the last two decades, a new and unifying concept of cellular organization has emerged i...
The evolution of multicellular animals (i.e., metazoans) from a unicellular ancestor is one of the m...
AbstractTyrosine phosphorylation is an essential element of signal transduction in multicellular ani...
Phosphotyrosine (pTyr) signaling, which plays a central role in cell-cell and cell-environment inter...
In 1986, Pawson's group recognized a region of homology between two oncogenic tyrosine kinases that ...
International audiencePhosphotyrosine (pTyr) signaling has evolved into a key cell-to-cell communica...
Src Homology 2 (SH2) domain-containing proteins are critical for mediating cellular signaling from r...
SH2 domains are integral to many animal signaling pathways. By interacting with specific phosphotyro...
In order for cells to respond to their environment, a series of regulated molecular events has to ta...
Multicellular animals use a three-part molecular toolkit to mediate phospho-tyrosine signaling: Tyro...
SH2 domains are long known prominent players in the field of phosphotyrosine recognition within sign...
SH2 domains are long known prominent players in the field of phosphotyrosine recognition within sign...
Phosphotyrosine (pY) signaling is instrumental to numerous cellular processes. pY recognition occurs...
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