Many cancer cells require exogenous glutamine for proliferation, supply of TCA cycle intermediates, lipid synthesis, mTOR activity, and neutralization of reactive oxygen species. In this issue of Cancer Cell, Jeon and colleagues identify chemotherapy-induced endoplasmic reticulum stress as a novel strategy to target glutamine dependence
Rare subpopulations of cancer stem cells (CSCs) have the ability to self-renew and are the primary d...
<div><p>Tumor cells display fundamental changes in metabolism and nutrient uptake in order to utiliz...
Glutamine is an essential nutrient for cancer cells. In this issue of Cancer Cell, Wang et al. (2010...
Many cancer cells require exogenous glutamine for proliferation, supply of TCA cycle intermediates, ...
Cells respond to metabolic stresses by reprogramming gene expression, degrading unneeded proteins an...
Identifying contexts in which cancer cells become addicted to specific nutrients is critical for dev...
The dependency of cancer cells on glutamine may be exploited therapeutically as a new strategy for t...
Reactive oxygen species (ROS) are byproducts of normal cellular processes. While low or moderate lev...
Glutamine can play a critical role in cellular growth in multiple cancers. Glutamine‐addicted cancer...
Several hallmarks of cancer cells are their display of metabolic changes and enhanced proliferation....
Metabolism rewiring is an important hallmark of cancers. Being one of the most abundant free amino a...
Glutamine metabolism has been proved to be dysregulated in many cancer cells, and is essential for p...
Tumor cells display fundamental changes in metabolism and nutrient uptake in order to utilize additi...
Increased consumption of glucose and glutamine are metabolic hallmarks of tumorigenesis. In this iss...
Recent work has highlighted glutaminase (GLS) as a key player in cancer cell metabolism, providing g...
Rare subpopulations of cancer stem cells (CSCs) have the ability to self-renew and are the primary d...
<div><p>Tumor cells display fundamental changes in metabolism and nutrient uptake in order to utiliz...
Glutamine is an essential nutrient for cancer cells. In this issue of Cancer Cell, Wang et al. (2010...
Many cancer cells require exogenous glutamine for proliferation, supply of TCA cycle intermediates, ...
Cells respond to metabolic stresses by reprogramming gene expression, degrading unneeded proteins an...
Identifying contexts in which cancer cells become addicted to specific nutrients is critical for dev...
The dependency of cancer cells on glutamine may be exploited therapeutically as a new strategy for t...
Reactive oxygen species (ROS) are byproducts of normal cellular processes. While low or moderate lev...
Glutamine can play a critical role in cellular growth in multiple cancers. Glutamine‐addicted cancer...
Several hallmarks of cancer cells are their display of metabolic changes and enhanced proliferation....
Metabolism rewiring is an important hallmark of cancers. Being one of the most abundant free amino a...
Glutamine metabolism has been proved to be dysregulated in many cancer cells, and is essential for p...
Tumor cells display fundamental changes in metabolism and nutrient uptake in order to utilize additi...
Increased consumption of glucose and glutamine are metabolic hallmarks of tumorigenesis. In this iss...
Recent work has highlighted glutaminase (GLS) as a key player in cancer cell metabolism, providing g...
Rare subpopulations of cancer stem cells (CSCs) have the ability to self-renew and are the primary d...
<div><p>Tumor cells display fundamental changes in metabolism and nutrient uptake in order to utiliz...
Glutamine is an essential nutrient for cancer cells. In this issue of Cancer Cell, Wang et al. (2010...
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