AbstractResuscitation of Mtb is crucial to the etiology of Tuberculosis, because latent tuberculosis is estimated to affect one-third of the world population. The resuscitation-promoting factor RpfB is mainly responsible for Mtb resuscitation from dormancy. Given the impact of latent Tuberculosis, RpfB represents an interesting target for tuberculosis drug discovery. However, no molecular models of substrate binding and catalysis are hitherto available for this enzyme. Here, we identified key interactions involved in substrate binding to RpfB by combining x-ray diffraction studies and computational approaches. The crystal structure of RpfB catalytic domain in complex with N,N′,N″-triacetyl-chitotriose, as described here, provides the first,...
Mycobacterium tuberculosis latent infection is maintained for years with no clinical symp-toms and n...
Tuberculosis (TB) is the most lethal bacterial infectious disease worldwide. It is notoriously diffi...
Mycobacterium tuberculosis is able to establish a non-replicating state and survive in an intracellu...
Resuscitation of Mtb is crucial to the etiology of Tuberculosis, because latent tuberculosis is esti...
AbstractResuscitation of Mtb is crucial to the etiology of Tuberculosis, because latent tuberculosis...
Inactivation of revival of Mycobacterium tuberculosis from dormancy is one of the main goals of the ...
<div><p>Inactivation of revival of <i>Mycobacterium tuberculosis</i> from dormancy is one of the mai...
RpfB is multidomain protein that is crucial for Mycobacterium tuberculosis resuscitation from dorman...
Background RpfB is a key factor in resuscitation from dormancy of Mycobacterium tuberculosis. This p...
Mycobacterium tuberculosis latent infection is maintained for years with no clinical symptoms and no...
<p>RpfB is multidomain protein that is crucial for <i>Mycobacterium tuberculosis</i> resuscitation f...
The increasing resistance to anti-tb drugs has enforced strategies for finding new drug targets agai...
Dihydrofolate reductase (DHFR), an essential enzyme in the folate pathway, is a potential target for...
<div><p>The enzymes decaprenylphosphoryl-β-D-ribose oxidase (DprE1) and decaprenylphosphoryl-β-D-rib...
International audienceResuscitation-promoting factor (RPF) proteins reactivate stationary-phase cult...
Mycobacterium tuberculosis latent infection is maintained for years with no clinical symp-toms and n...
Tuberculosis (TB) is the most lethal bacterial infectious disease worldwide. It is notoriously diffi...
Mycobacterium tuberculosis is able to establish a non-replicating state and survive in an intracellu...
Resuscitation of Mtb is crucial to the etiology of Tuberculosis, because latent tuberculosis is esti...
AbstractResuscitation of Mtb is crucial to the etiology of Tuberculosis, because latent tuberculosis...
Inactivation of revival of Mycobacterium tuberculosis from dormancy is one of the main goals of the ...
<div><p>Inactivation of revival of <i>Mycobacterium tuberculosis</i> from dormancy is one of the mai...
RpfB is multidomain protein that is crucial for Mycobacterium tuberculosis resuscitation from dorman...
Background RpfB is a key factor in resuscitation from dormancy of Mycobacterium tuberculosis. This p...
Mycobacterium tuberculosis latent infection is maintained for years with no clinical symptoms and no...
<p>RpfB is multidomain protein that is crucial for <i>Mycobacterium tuberculosis</i> resuscitation f...
The increasing resistance to anti-tb drugs has enforced strategies for finding new drug targets agai...
Dihydrofolate reductase (DHFR), an essential enzyme in the folate pathway, is a potential target for...
<div><p>The enzymes decaprenylphosphoryl-β-D-ribose oxidase (DprE1) and decaprenylphosphoryl-β-D-rib...
International audienceResuscitation-promoting factor (RPF) proteins reactivate stationary-phase cult...
Mycobacterium tuberculosis latent infection is maintained for years with no clinical symp-toms and n...
Tuberculosis (TB) is the most lethal bacterial infectious disease worldwide. It is notoriously diffi...
Mycobacterium tuberculosis is able to establish a non-replicating state and survive in an intracellu...