Arc/Arg3.1 Is Essential for the Consolidation of Synaptic Plasticity and Memories
- Plath, Niels
- Ohana, Ora
- Dammermann, Björn
- Errington, Mick L.
- Schmitz, Dietmar
- Gross, Christina
- Mao, Xiaosong
- Engelsberg, Arne
- Mahlke, Claudia
- Welzl, Hans
- Kobalz, Ursula
- Stawrakakis, Anastasia
- Fernandez, Esperanza
- Waltereit, Robert
- Bick-Sander, Anika
- Therstappen, Eric
- Cooke, Sam F.
- Blanquet, Veronique
- Wurst, Wolfgang
- Salmen, Benedikt
- Bösl, Michael R.
- Lipp, Hans-Peter
- Grant, Seth G.N.
- Bliss, Tim V.P.
- Wolfer, David P.
- Kuhl, Dietmar
DOIAbstract
SummaryArc/Arg3.1 is robustly induced by plasticity-producing stimulation and specifically targeted to stimulated synaptic areas. To investigate the role of Arc/Arg3.1 in synaptic plasticity and learning and memory, we generated Arc/Arg3.1 knockout mice. These animals fail to form long-lasting memories for implicit and explicit learning tasks, despite intact short-term memory. Moreover, they exhibit a biphasic alteration of hippocampal long-term potentiation in the dentate gyrus and area CA1 with an enhanced early and absent late phase. In addition, long-term depression is significantly impaired. Together, these results demonstrate a critical role for Arc/Arg3.1 in the consolidation of enduring synaptic plasticity and memory storage
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