Actin Filament Length Tunes Elasticity of Flexibly Cross-Linked Actin Networks
- Kasza, K.E.
- Broedersz, C.P.
- Koenderink, G.H.
- Lin, Y.C.
- Messner, W.
- Millman, E.A.
- Nakamura, F.
- Stossel, T.P.
- MacKintosh, F.C.
- Weitz, D.A.
Publication date
August 2010
DOI Publisher
Biophysical Society. Published by Elsevier Inc.Abstract
AbstractNetworks of the cytoskeletal biopolymer actin cross-linked by the compliant protein filamin form soft gels that stiffen dramatically under shear stress. We demonstrate that the elasticity of these networks shows a strong dependence on the mean length of the actin polymers, unlike networks with small, rigid cross-links. This behavior is in agreement with a model of rigid filaments connected by multiple flexible linkers
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