SummaryThe developing retina generates spontaneous glutamatergic (stage III) waves of activity that sequentially recruit neighboring ganglion cells with opposite light responses (ON and OFF RGCs). This activity pattern is thought to help establish parallel ON and OFF pathways in downstream visual areas. The circuits that produce stage III waves and desynchronize ON and OFF RGC firing remain obscure. Using dual patch-clamp recordings, we find that ON and OFF RGCs receive sequential excitatory input from ON and OFF cone bipolar cells (CBCs), respectively. This input sequence is generated by crossover circuits, in which ON CBCs control glutamate release from OFF CBCs via diffusely stratified inhibitory amacrine cells. In addition, neighboring ...
Spontaneous rhythmic activity is a hallmark feature of the developing retina, where propagating reti...
SummaryDuring development, retinal axons project coarsely within their visual targets before refinin...
SummaryIn the few days prior to eye-opening in mice, the excitatory drive underlying waves switches ...
SummaryThe developing retina generates spontaneous glutamatergic (stage III) waves of activity that ...
SummaryPatterns of coordinated spontaneous activity have been proposed to guide circuit refinement i...
Many circuits in the developing nervous system generate spontaneous activity. This phenomenon has be...
The retina is complex neural network that conveys visual information to the brain. It is composed o...
Throughout the developing nervous system, spontaneous oscillatory patterns of activity have been obs...
The retina is complex neural network that conveys visual information to the brain. It is composed o...
SummaryPatterns of coordinated spontaneous activity have been proposed to guide circuit refinement i...
The intricate patterning and complex circuitry of the nervous system beg the question of how such pr...
The development of neural circuits is perhaps one of the most fascinating phenomena of nature. Neura...
The development of neural circuits is perhaps one of the most fascinating phenomena of nature. Neura...
Spontaneous retinal activity mediated by glutamatergic neurotransmission-so-called "Stage 3" retinal...
SummaryThe elaboration of nascent synaptic connections into highly ordered neural circuits is an int...
Spontaneous rhythmic activity is a hallmark feature of the developing retina, where propagating reti...
SummaryDuring development, retinal axons project coarsely within their visual targets before refinin...
SummaryIn the few days prior to eye-opening in mice, the excitatory drive underlying waves switches ...
SummaryThe developing retina generates spontaneous glutamatergic (stage III) waves of activity that ...
SummaryPatterns of coordinated spontaneous activity have been proposed to guide circuit refinement i...
Many circuits in the developing nervous system generate spontaneous activity. This phenomenon has be...
The retina is complex neural network that conveys visual information to the brain. It is composed o...
Throughout the developing nervous system, spontaneous oscillatory patterns of activity have been obs...
The retina is complex neural network that conveys visual information to the brain. It is composed o...
SummaryPatterns of coordinated spontaneous activity have been proposed to guide circuit refinement i...
The intricate patterning and complex circuitry of the nervous system beg the question of how such pr...
The development of neural circuits is perhaps one of the most fascinating phenomena of nature. Neura...
The development of neural circuits is perhaps one of the most fascinating phenomena of nature. Neura...
Spontaneous retinal activity mediated by glutamatergic neurotransmission-so-called "Stage 3" retinal...
SummaryThe elaboration of nascent synaptic connections into highly ordered neural circuits is an int...
Spontaneous rhythmic activity is a hallmark feature of the developing retina, where propagating reti...
SummaryDuring development, retinal axons project coarsely within their visual targets before refinin...
SummaryIn the few days prior to eye-opening in mice, the excitatory drive underlying waves switches ...