A comparison of the structure of ciprofloxacin and grepafloxacin shows that the two compounds are similar, with two exceptions: grepafloxacin has a methyl group at the 5 position and a methyl group attached to the 7-piperazinyl substituent. At the 1 position, both compounds have a cyclopropyl group, which is important for potency, but limits anaerobic activity. The methylpiperazine at position 7 in grepafloxacin is associated with its enhanced Gram-positive activity and long half-life. The methyl group at R5 is also thought to enhance Gram-positive activity. Ciprofloxacin's piperazine group at the 7 position is associated with good Gram-negative activity. Grepafloxacin's Gram-negative activity is comparable to that of ciprofloxacin's agains...
An understanding of the pharmacokinetic and pharmacodynamic properties of antimicrobial agents enabl...
considerably improved over that of C-H analogues. The new veterinary fluoroquinolone pradofloxacin b...
目的测定格帕沙星及对照药环丙沙星等对500株临床分离菌的体外抗菌活性.方法琼脂二倍稀释法和肉汤二倍稀释法.结果格帕沙星抗革兰阳性球菌作用优于环丙沙星和氧氟沙星,与司巴沙星相当.尤其对于MSSA和链球菌...
A comparison of the structure of ciprofloxacin and grepafloxacin shows that the two compounds are si...
Grepafloxacin is a new broad-spectrum fluoroquinolone characterized by having a methyl-substituted p...
Grepafloxin has an extremely broad spectrum of activity. Its activity against Gram-positive bacteria...
Pharmacokinetic and tissue penetration studies of grepafloxacin, a new broad-spectrum fluoroquinolon...
A single 400-mg oral dose of grepafloxacin (OPC-17116) was given to each of six healthy male volunte...
The fluoroquinolone class of antimicrobials has been in clinical use for over 13 years. During that ...
The present paper evaluates the clinical trial program in lower respiratory tract infections treated...
The relationship between the structures of quinolones and their anti-Mycobacterium avium activities ...
Fluoroquinolones are frequently usedfor the treatment of a variety of in-fectious diseases. This dru...
In vitro activities of LB20304a were compared with those of grepafloxacin (OPC-17116), Q-35, ciprofl...
The aim of the work. Among all the representatives of four generations of fluoroquinolones ciproflox...
Fluoroquinolone-resistant mutants were selected from Staphylococcus aureus NCTC 8532 (F77), and two ...
An understanding of the pharmacokinetic and pharmacodynamic properties of antimicrobial agents enabl...
considerably improved over that of C-H analogues. The new veterinary fluoroquinolone pradofloxacin b...
目的测定格帕沙星及对照药环丙沙星等对500株临床分离菌的体外抗菌活性.方法琼脂二倍稀释法和肉汤二倍稀释法.结果格帕沙星抗革兰阳性球菌作用优于环丙沙星和氧氟沙星,与司巴沙星相当.尤其对于MSSA和链球菌...
A comparison of the structure of ciprofloxacin and grepafloxacin shows that the two compounds are si...
Grepafloxacin is a new broad-spectrum fluoroquinolone characterized by having a methyl-substituted p...
Grepafloxin has an extremely broad spectrum of activity. Its activity against Gram-positive bacteria...
Pharmacokinetic and tissue penetration studies of grepafloxacin, a new broad-spectrum fluoroquinolon...
A single 400-mg oral dose of grepafloxacin (OPC-17116) was given to each of six healthy male volunte...
The fluoroquinolone class of antimicrobials has been in clinical use for over 13 years. During that ...
The present paper evaluates the clinical trial program in lower respiratory tract infections treated...
The relationship between the structures of quinolones and their anti-Mycobacterium avium activities ...
Fluoroquinolones are frequently usedfor the treatment of a variety of in-fectious diseases. This dru...
In vitro activities of LB20304a were compared with those of grepafloxacin (OPC-17116), Q-35, ciprofl...
The aim of the work. Among all the representatives of four generations of fluoroquinolones ciproflox...
Fluoroquinolone-resistant mutants were selected from Staphylococcus aureus NCTC 8532 (F77), and two ...
An understanding of the pharmacokinetic and pharmacodynamic properties of antimicrobial agents enabl...
considerably improved over that of C-H analogues. The new veterinary fluoroquinolone pradofloxacin b...
目的测定格帕沙星及对照药环丙沙星等对500株临床分离菌的体外抗菌活性.方法琼脂二倍稀释法和肉汤二倍稀释法.结果格帕沙星抗革兰阳性球菌作用优于环丙沙星和氧氟沙星,与司巴沙星相当.尤其对于MSSA和链球菌...