The epidermis is an active site of lipid metabolism, and the synthesis of fatty acids and cholesterol is required for cutaneous homeostasis. Liver X receptor-α (LXRα) and LXRβ are nuclear receptors that are activated by oxysterols and regulate cholesterol and fatty acid metabolism. LXRs, predominantly LXRβ, have been shown to be involved in keratinocyte differentiation and epidermal permeability barrier function. Although LXR regulates hepatic lipogenesis by inducing sterol-regulatory element-binding protein-1c (SREBP-1c), SREBP-1c induction by LXR in the epidermis has not been studied. In this study, we report that SREBP-1c mRNA increased during differentiation of human keratinocyte HaCaT cells and that LXR agonist effectively induced expr...
Liver X receptors α and β (LXRα and LXRβ) are nuclear receptors with pivotal roles in the transcript...
SummaryMeiosis-activating sterols (MAS) are substrates of SC4MOL and NSDHL in the cholesterol pathwa...
The liver X receptors (LXRs) are nuclear receptors that play central roles in the transcriptional co...
The epidermis is an active site of lipid metabolism, and the synthesis of fatty acids and cholestero...
Ligands and activators of the nuclear hormone receptor superfamily are important in the regulation o...
Oxysterols, via activation of liver X receptor (LXR), regulate keratinocyte differentiation by stimu...
Liver X receptor-α and -β are members of the nuclear hormone receptor superfamily that heterodimeriz...
ATP-binding cassette (ABC) transporter, family 12 (ABCA12), a member of the ABC superfamily, facilit...
The liver X receptor (LXR) was demonstrated to play a key role in cholesterol metabolism in liver, i...
Liver X receptors (LXRs) are nuclear receptors that act as ligand-activated transcription factors re...
Plasticity in epithelial tissues relates to processes of embryonic development, tissue fibrosis and ...
Differentiation of sebocytes is strongly associated with enhanced lipid synthesis and accumulation i...
Plasticity in epithelial tissues relates to processes of embryonic development, tissue fibrosis and ...
The liver X receptors (LXRs) sense oxysterols and regulate genes involved in cholesterol metabolism....
Background: The main functions of the skin are to protect against environmental insults and prevent ...
Liver X receptors α and β (LXRα and LXRβ) are nuclear receptors with pivotal roles in the transcript...
SummaryMeiosis-activating sterols (MAS) are substrates of SC4MOL and NSDHL in the cholesterol pathwa...
The liver X receptors (LXRs) are nuclear receptors that play central roles in the transcriptional co...
The epidermis is an active site of lipid metabolism, and the synthesis of fatty acids and cholestero...
Ligands and activators of the nuclear hormone receptor superfamily are important in the regulation o...
Oxysterols, via activation of liver X receptor (LXR), regulate keratinocyte differentiation by stimu...
Liver X receptor-α and -β are members of the nuclear hormone receptor superfamily that heterodimeriz...
ATP-binding cassette (ABC) transporter, family 12 (ABCA12), a member of the ABC superfamily, facilit...
The liver X receptor (LXR) was demonstrated to play a key role in cholesterol metabolism in liver, i...
Liver X receptors (LXRs) are nuclear receptors that act as ligand-activated transcription factors re...
Plasticity in epithelial tissues relates to processes of embryonic development, tissue fibrosis and ...
Differentiation of sebocytes is strongly associated with enhanced lipid synthesis and accumulation i...
Plasticity in epithelial tissues relates to processes of embryonic development, tissue fibrosis and ...
The liver X receptors (LXRs) sense oxysterols and regulate genes involved in cholesterol metabolism....
Background: The main functions of the skin are to protect against environmental insults and prevent ...
Liver X receptors α and β (LXRα and LXRβ) are nuclear receptors with pivotal roles in the transcript...
SummaryMeiosis-activating sterols (MAS) are substrates of SC4MOL and NSDHL in the cholesterol pathwa...
The liver X receptors (LXRs) are nuclear receptors that play central roles in the transcriptional co...