Magnesium availability affects many cellular functions that are critical for tumour growth and spreading, such as proliferation, metabolism and angiogenesis. In vivo, magnesium deficiency, and the resulting inflammation, can trigger both anti- and pro-tumour effects. Recent experimental evidence indicates that altered expression of the transient receptor potential melastatin, type 7 (TRPM7) epithelial magnesium channel is a frequent finding in cancer cells and human tumour tissues, and correlates with cell proliferation and/or migration. We review the role of TRPM7 in tumour development, with particular regard to its channelling function mediating both Ca(2+) and Mg(2+) influx, as well as its kinase activity, likely regulating actomyosin co...
Intestinal magnesium (Mg) uptake is essential for systemic Mg homeostasis. Colon cells express the t...
AbstractTransient receptor potential (TRP) proteins are a family of ion channels, which are responsi...
Pancreatic ductal adenocarcinoma (PDAC) is the most common form of pancreatic cancer. It is characte...
International audienceTransient Receptor Potential Melastatin-related 7 (TRPM7) is a non-selective c...
The transient receptor potential melastatin-subfamily member 7 (TRPM7) is a ubiquitously expressed c...
Abstract Background Magnesium (Mg2+) is an essential cation implicated in carcinogenesis, solid tumo...
International audienceIntestinal magnesium (Mg) uptake is essential for systemic Mg homeostasis. Col...
The transient receptor potential melastatin-subfamily member 7 (TRPM7) is a ubiquitously expressed c...
Magnesium is directly involved in the control of cell growth and survival, but its role in cancer bi...
TRPM7 is a ubiquitously expressed cation channel with a fused alpha kinase domain. It is highly perm...
Derangement of magnesium homeostasis underlies the pathophysiology of many diseases, including cance...
The relationship between magnesium and cancer is not as simple as could be assumed from the well-est...
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a very poor prognosis. Ther...
Neoplastic cells accumulate magnesium, an event which provides selective advantages and is frequentl...
Evidence has accumulated to suggest that magnesium might play a role in controlling angiogenesis. Si...
Intestinal magnesium (Mg) uptake is essential for systemic Mg homeostasis. Colon cells express the t...
AbstractTransient receptor potential (TRP) proteins are a family of ion channels, which are responsi...
Pancreatic ductal adenocarcinoma (PDAC) is the most common form of pancreatic cancer. It is characte...
International audienceTransient Receptor Potential Melastatin-related 7 (TRPM7) is a non-selective c...
The transient receptor potential melastatin-subfamily member 7 (TRPM7) is a ubiquitously expressed c...
Abstract Background Magnesium (Mg2+) is an essential cation implicated in carcinogenesis, solid tumo...
International audienceIntestinal magnesium (Mg) uptake is essential for systemic Mg homeostasis. Col...
The transient receptor potential melastatin-subfamily member 7 (TRPM7) is a ubiquitously expressed c...
Magnesium is directly involved in the control of cell growth and survival, but its role in cancer bi...
TRPM7 is a ubiquitously expressed cation channel with a fused alpha kinase domain. It is highly perm...
Derangement of magnesium homeostasis underlies the pathophysiology of many diseases, including cance...
The relationship between magnesium and cancer is not as simple as could be assumed from the well-est...
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a very poor prognosis. Ther...
Neoplastic cells accumulate magnesium, an event which provides selective advantages and is frequentl...
Evidence has accumulated to suggest that magnesium might play a role in controlling angiogenesis. Si...
Intestinal magnesium (Mg) uptake is essential for systemic Mg homeostasis. Colon cells express the t...
AbstractTransient receptor potential (TRP) proteins are a family of ion channels, which are responsi...
Pancreatic ductal adenocarcinoma (PDAC) is the most common form of pancreatic cancer. It is characte...