SummaryRetinoic acid (RA) triggers antiproliferative effects in tumor cells, and therefore RA and its synthetic analogs have great potential as anticarcinogenic agents. Retinoic acid receptors (RARs) mediate RA effects by directly regulating gene expression. To define the genetic network regulated by RARs in breast cancer, we identified RAR genomic targets using chromatin immunoprecipitation and expression analysis. We found that RAR binding throughout the genome is highly coincident with estrogen receptor α (ERα) binding, resulting in a widespread crosstalk of RA and estrogen signaling to antagonistically regulate breast cancer-associated genes. ERα- and RAR-binding sites appear to be coevolved on a large scale throughout the human genome,...
Retinoic acid (RA) and its synthetic derivatives, retinoids, have been established as promising anti...
More than 70% of breast cancers in women require estrogens for cell proliferation and survival. 17β-...
More than 70% of breast cancers in women require estrogens for cell proliferation and survival. 17β-...
SummaryRetinoic acid (RA) triggers antiproliferative effects in tumor cells, and therefore RA and it...
Molecular segmentation of breast cancer allows identification of small groups of patients who presen...
In the present report, we investigated the action of retinoic acid (RA) on the transactivation of th...
Estrogen receptor alpha (ERα) and retinoic acid receptors (RARs) play important and opposite roles i...
Estrogen receptor alpha (ERα) and retinoic acid receptors (RARs) play important and opposite roles i...
Retinoic acid (RA), the major bioactive metabolite of retinol or vitamin A, induces a spectrum of pl...
Retinoic acid (RA), the major bioactive metabolite of retinol or vitamin A, induces a spectrum of pl...
Retinoic acid (RA), the major bioactive metabolite of retinol or vitamin A, induces a spectrum of pl...
Retinoic acid (RA), the major bioactive metabolite of retinol or vitamin A, induces a spectrum of pl...
Retinoic acid (RA), the major bioactive metabolite of retinol or vitamin A, induces a spectrum of pl...
Retinoic acid (RA), the major bioactive metabolite of retinol or vitamin A, induces a spectrum of pl...
More than 70% of breast cancers in women require estrogens for cell proliferation and survival. 17β-...
Retinoic acid (RA) and its synthetic derivatives, retinoids, have been established as promising anti...
More than 70% of breast cancers in women require estrogens for cell proliferation and survival. 17β-...
More than 70% of breast cancers in women require estrogens for cell proliferation and survival. 17β-...
SummaryRetinoic acid (RA) triggers antiproliferative effects in tumor cells, and therefore RA and it...
Molecular segmentation of breast cancer allows identification of small groups of patients who presen...
In the present report, we investigated the action of retinoic acid (RA) on the transactivation of th...
Estrogen receptor alpha (ERα) and retinoic acid receptors (RARs) play important and opposite roles i...
Estrogen receptor alpha (ERα) and retinoic acid receptors (RARs) play important and opposite roles i...
Retinoic acid (RA), the major bioactive metabolite of retinol or vitamin A, induces a spectrum of pl...
Retinoic acid (RA), the major bioactive metabolite of retinol or vitamin A, induces a spectrum of pl...
Retinoic acid (RA), the major bioactive metabolite of retinol or vitamin A, induces a spectrum of pl...
Retinoic acid (RA), the major bioactive metabolite of retinol or vitamin A, induces a spectrum of pl...
Retinoic acid (RA), the major bioactive metabolite of retinol or vitamin A, induces a spectrum of pl...
Retinoic acid (RA), the major bioactive metabolite of retinol or vitamin A, induces a spectrum of pl...
More than 70% of breast cancers in women require estrogens for cell proliferation and survival. 17β-...
Retinoic acid (RA) and its synthetic derivatives, retinoids, have been established as promising anti...
More than 70% of breast cancers in women require estrogens for cell proliferation and survival. 17β-...
More than 70% of breast cancers in women require estrogens for cell proliferation and survival. 17β-...