AbstractTNF-α acts on the hypothalamus modulating food intake and energy expenditure through mechanisms incompletely elucidated. Here, we explore the hypothesis that, to modulate insulin-induced anorexigenic signaling in hypothalamus, TNF-α requires the synthesis of NO. TNF-α activates signal transduction through JNK and p38 in hypothalamus, peaking at 10−8M. This is accompanied by the induction of expression of the inducible and neuronal forms of NOS, in both cases peaking at 10−12M. In addition, TNF-α stimulates NOS catalytic activity. Pre-treatment with TNF-α at a low dose (10−12M) inhibits insulin-dependent anorexigenic signaling, and this effect is abolished in iNOS but not in nNOS knockout mice
1939-327X (Electronic) Journal Article Research Support, Non-U.S. Gov'tOBJECTIVE: Insulin plays an i...
1939-327X (Electronic) Journal Article Research Support, Non-U.S. Gov'tOBJECTIVE: Insulin plays an i...
Anorexia and weight loss are prevalent in infectious diseases. To investigate the molecular mechanis...
TNF-alpha acts on the hypothalamus modulating food intake and energy expenditure through mechanisms ...
TNF-alpha acts on the hypothalamus modulating food intake and energy expenditure through mechanisms ...
AbstractTNF-α acts on the hypothalamus modulating food intake and energy expenditure through mechani...
Acting in the hypothalamus, tumor necrosis factor-alpha (TNF-alpha) produces a potent anorexigenic e...
Acting in the hypothalamus, tumor necrosis factor-alpha (TNF-alpha) produces a potent anorexigenic e...
Durante as últimas décadas tem se observado um aumento surpreendente na prevalência de obesidade e d...
Orientador: Licio Augusto VellosoDissertação (mestrado) - Universidade Estadual de Campinas, Faculda...
International audienceObjectives: Infections, cancer, and systemic inflammation elicit anorexia. Des...
International audienceObjectives: Infections, cancer, and systemic inflammation elicit anorexia. Des...
International audienceObjectives: Infections, cancer, and systemic inflammation elicit anorexia. Des...
AbstractWe have associated functional and molecular studies of insulin and leptin to investigate the...
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Ci...
1939-327X (Electronic) Journal Article Research Support, Non-U.S. Gov'tOBJECTIVE: Insulin plays an i...
1939-327X (Electronic) Journal Article Research Support, Non-U.S. Gov'tOBJECTIVE: Insulin plays an i...
Anorexia and weight loss are prevalent in infectious diseases. To investigate the molecular mechanis...
TNF-alpha acts on the hypothalamus modulating food intake and energy expenditure through mechanisms ...
TNF-alpha acts on the hypothalamus modulating food intake and energy expenditure through mechanisms ...
AbstractTNF-α acts on the hypothalamus modulating food intake and energy expenditure through mechani...
Acting in the hypothalamus, tumor necrosis factor-alpha (TNF-alpha) produces a potent anorexigenic e...
Acting in the hypothalamus, tumor necrosis factor-alpha (TNF-alpha) produces a potent anorexigenic e...
Durante as últimas décadas tem se observado um aumento surpreendente na prevalência de obesidade e d...
Orientador: Licio Augusto VellosoDissertação (mestrado) - Universidade Estadual de Campinas, Faculda...
International audienceObjectives: Infections, cancer, and systemic inflammation elicit anorexia. Des...
International audienceObjectives: Infections, cancer, and systemic inflammation elicit anorexia. Des...
International audienceObjectives: Infections, cancer, and systemic inflammation elicit anorexia. Des...
AbstractWe have associated functional and molecular studies of insulin and leptin to investigate the...
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Ci...
1939-327X (Electronic) Journal Article Research Support, Non-U.S. Gov'tOBJECTIVE: Insulin plays an i...
1939-327X (Electronic) Journal Article Research Support, Non-U.S. Gov'tOBJECTIVE: Insulin plays an i...
Anorexia and weight loss are prevalent in infectious diseases. To investigate the molecular mechanis...