Plasma concentration of IL-6 and TNF-α and its relationship with zincemia in obese women

AbstractObjectiveIn obesity, the excessive adipose tissue increases the synthesis of inflammatory cytokines, which appear to alter the metabolism of minerals, such as zinc. However, the mechanisms involved remain unclear. This study investigated whether the concentrations of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in plasma can to influence biochemical parameters of zinc in obese women.MethodsSeventy-six pre-menopausal women, aged between 20 and 50 years, were divided into two groups: the case group, composed of obese women (n=37) and the control group, composed of non-obese women (n=39). Analysis of the plasmatic and erythrocytary zinc, and plasmatic cytokines were conducted by flame atomic absorption spectrophotometry and by ELISA, respectively.ResultsThe plasmatic zinc and concentrations of IL-6 in plasma did not show significant differences between obese women and controls (p>0.05). The erythrocytary zinc was 36.4±15.0μg/gHb in the case group, and 45.4±14.3μg/gHb (p=0.025) in the control group. The concentrations of TNF-α in plasma were 42.0±11.9pg/mL and 19.0±1.0pg/mL in obese women and in controls, respectively (p