Lethality of cytochalasin B and other compounds isolated from fungus Aspergillus sp. (Trichocomaceae) endophyte of Bauhinia guianensis (Fabaceae)
- Feitosa, André de O.
- Dias, Amanda Cristina S.
- Ramos, Gisele da C.
- Bitencourt, Heriberto R.
- Siqueira, José Edson S.
- Marinho, Patrícia Santana B.
- Barison, Andersson
- Ocampos, Fernanda M.M.
- Marinho, Andrey Moacir do R.
Publication date
September 2016
DOI Publisher
Asociación Argentina de Microbiología. Published by Elsevier España, S.L.U.Abstract
AbstractEndophytic fungi are fungi that colonize internal tissues of plants; several biologically active compounds have been isolated from these fungi. There are few studies of compounds isolated from endophytic fungi of Amazon plants. Thus, this study aimed the isolation and structural identification of ergosterol (1), ergosterol peroxide (2), mevalonolactone (3), cytochalasin B (4) and cytochalasin H (5) from Aspergillus sp. EJC 04, an endophytic fungus from Bauhinia guianensis. The cytochalasin B (4) and the diacetate derivative of cytochalasin B (4a) showed high lethality in the brine shrimp assay. This is the first occurrence of cytochalasins in Amazonian endophytic fungi from B. guianensis
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