Sensitivity of Mouse Skh:HR-2 to Ultraviolet Radiation: Melanocyte Inactivation
- Warren, Raphael
- Gardner, Paul A.
- Reed, Jody C.
Publication date
March 1987
DOI Publisher
The Society for Investigative Dermatology, Inc. Published by Elsevier Inc.Abstract
The hairless mouse, Skh:HR-2, was exposed to doses of ultraviolet (UV) radiation known to induce skin pigmentation. Three parameters associated with perturbations in skin pigmentation were monitored following UV exposure. These include spectroscopy (skin darkness), histology (melanocyte density), and biochemistry (melanin). Within 90mm of UV exposure, the skin became lighter. This was associated with a reduction of quantifiable melanin and the inactivation of epidermal melanocytes
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