Assessment of the efficacy of desmopressin in treatment of Primary Monosymptomatic Nocturnal Enuresis in Egyptian children

AbstractBackgroundEnuresis is defined as a normal void occurring at an inappropriate social time or place. The treatment approach for enuresis is controversial due to a lack of consensus as to the exact causes of nocturnal enuresis.AimAim was to assess the efficacy of desmopressin therapy in the treatment of Primary Monosymptomatic Nocturnal Enuresis (PMNE) in Egyptian children.MethodThe study assessed 40 children aged 6–15years suffering from PMNE. They were divided into 2 groups; Group 1 (20 patients) were on desmopressin tablets (0.2mg) once daily before bedtime for 8weeks in addition to behavioral modifications. Group 2 received only behavioral modifications. Both groups were followed up for 8weeks of treatment, and then another 8weeks to detect relapse.ResultsThe wetting frequency decreased during treatment by 70% in Group 1 and 65% in Group 2. However, this difference was not statistically significantly different. The complete and partial response rates were 45% and 25% respectively in Group 1 and were 35% and 30% respectively in Group 2.ConclusionThere is a highly significant decrease in wet nights in response to either desmopressin or behavioral therapy. However, the difference is not statistically significant. Also, it was found that relapsers (mainly early relapsers) are significantly more encountered in patients treated by desmopressin