AbstractThe data described here is related to the research article titled (Gabl et al., 2016) [1]. Pepducins with peptide sequence derived from one of the intracellular domains of a given G-protein coupled receptor (GPCR) can either activate or inhibit cell functions. Here we include data on human neutrophil function induced by pepducins derived from β2AR (ICL3-8) and CXCR4 (ATI-2341), respectively. ICL3-8 exerts neither direct activating effect on the NADPH-oxidase as measured by superoxide release nor inhibitory effect on FPR signaling. ATI-2341 dose-dependently triggers neutrophil activation and these cells were subsequently desensitized in their response to FPR2 specific agonists F2Pal10 and WKYMVM. Moreover, the ATI-2341 response is in...
<p><b>A)</b> Human neutrophils (10<sup>5</sup> cells) were activated by the pepducin F2Pal<sub>16</s...
The chemotactic recruitment of neutrophils, the most abundant white blood cell in human circulation,...
<p><b>A)</b> Mouse neutrophils (5 x 10<sup>4</sup> cells) were activated by addition of the mF1Pal<s...
The data described here is related to the research article titled (Gabl et al., 2016) [1]. Pepducins...
AbstractThe data described here is related to the research article titled (Gabl et al., 2016) [1]. P...
AbstractPepducins constitute a unique class of G-protein coupled receptor (GPCR) modulating lipopept...
AbstractLipidated peptides (pepducins) can activate certain G-protein coupled receptors (GPCRs) thro...
Neutrophil pattern recognition receptors belonging to the G-protein coupled receptor (GPCR) family p...
Neutrophils are important effector cells of the innate immune system and in the regulation of inflam...
A pepducin is a lipopeptide containing a peptide sequence that is identical to one of the intracellu...
We recently described a novel receptor cross-talk mechanism in neutrophils, unique in that the signa...
<p><b>A.</b> Primary human neutrophils were activated by F2Pal<sub>10</sub> (500 nM) in the absence ...
For-Met-Leu-Phe-OH (fMLP) and its derivative methyl ester, fMLP-OMe, represent highly potent chemoat...
Recruitment and activation of neutrophils at sites of infection/inflammation relies largely on the s...
Phagocytic cells such as neutrophil granulocytes and monocytes are an essential part of our innate i...
<p><b>A)</b> Human neutrophils (10<sup>5</sup> cells) were activated by the pepducin F2Pal<sub>16</s...
The chemotactic recruitment of neutrophils, the most abundant white blood cell in human circulation,...
<p><b>A)</b> Mouse neutrophils (5 x 10<sup>4</sup> cells) were activated by addition of the mF1Pal<s...
The data described here is related to the research article titled (Gabl et al., 2016) [1]. Pepducins...
AbstractThe data described here is related to the research article titled (Gabl et al., 2016) [1]. P...
AbstractPepducins constitute a unique class of G-protein coupled receptor (GPCR) modulating lipopept...
AbstractLipidated peptides (pepducins) can activate certain G-protein coupled receptors (GPCRs) thro...
Neutrophil pattern recognition receptors belonging to the G-protein coupled receptor (GPCR) family p...
Neutrophils are important effector cells of the innate immune system and in the regulation of inflam...
A pepducin is a lipopeptide containing a peptide sequence that is identical to one of the intracellu...
We recently described a novel receptor cross-talk mechanism in neutrophils, unique in that the signa...
<p><b>A.</b> Primary human neutrophils were activated by F2Pal<sub>10</sub> (500 nM) in the absence ...
For-Met-Leu-Phe-OH (fMLP) and its derivative methyl ester, fMLP-OMe, represent highly potent chemoat...
Recruitment and activation of neutrophils at sites of infection/inflammation relies largely on the s...
Phagocytic cells such as neutrophil granulocytes and monocytes are an essential part of our innate i...
<p><b>A)</b> Human neutrophils (10<sup>5</sup> cells) were activated by the pepducin F2Pal<sub>16</s...
The chemotactic recruitment of neutrophils, the most abundant white blood cell in human circulation,...
<p><b>A)</b> Mouse neutrophils (5 x 10<sup>4</sup> cells) were activated by addition of the mF1Pal<s...