AbstractThe present paper reports on the influence of the route of administration and liposome stability on the protective effect of liposome encapsulation of two model antitumor agents, mitoxantrone and doxorubicin. The results demonstrate that liposome encapsulation can protect surrounding tissue from the cytotoxic effects of the drugs after subcutaneous (sc) and intramuscular (im) administration. The route of administration is an important factor influencing tissue damage. Liposomal mitoxantrone caused much less tissue irritation after im injection than after sc injection. Liposome stability is also an important factor. Liposomes composed of ‘fluid-state’ phospholipids only delayed the damaging effects of doxorubicin when injected sc. Li...
Liposomes, which are vesicles composed of a phospholipid bilayer surrounding an aqueous milieu, repr...
A previous study suggested that drug release is the dominating factor controlling biological activit...
Lately, the usefulness of liposomal drug delivery systems has been debated. To better understand the...
AbstractThe present paper reports on the influence of the route of administration and liposome stabi...
Mitoxantrone (MTO) was incorporated into small unilamellar liposomes by formation of a complex betwe...
The toxicity and efficacy properties of doxorubicin entrapped inside liposomes are sensitive to the ...
Cancer is a life-threatening disease contributing to ~3.4 million deaths worldwide. There are variou...
Cancer is a life-threatening disease contributing to ~3.4 million deaths worldwide. There are variou...
Forty years of liposome research have demonstrated that the anti-tumor efficacy of liposomal therapi...
Although liposomal accumulation at the target site is an important issue, the critical parameter de...
One of the greatest benefits of liposomal encapsulation of therapeutic drugs is the tendency for th...
Liposomes hold great potential as gene and drug delivery vehicles due to their biocompatibility and ...
One of the greatest benefits of liposomal encapsulation of therapeutic drugs is the tendency for th...
In this research the selective delivery of drug by liposomes to solid tumors as compared to healthy ...
<div><p>Various liposomal drug carriers have been developed to overcome short plasma half-life and t...
Liposomes, which are vesicles composed of a phospholipid bilayer surrounding an aqueous milieu, repr...
A previous study suggested that drug release is the dominating factor controlling biological activit...
Lately, the usefulness of liposomal drug delivery systems has been debated. To better understand the...
AbstractThe present paper reports on the influence of the route of administration and liposome stabi...
Mitoxantrone (MTO) was incorporated into small unilamellar liposomes by formation of a complex betwe...
The toxicity and efficacy properties of doxorubicin entrapped inside liposomes are sensitive to the ...
Cancer is a life-threatening disease contributing to ~3.4 million deaths worldwide. There are variou...
Cancer is a life-threatening disease contributing to ~3.4 million deaths worldwide. There are variou...
Forty years of liposome research have demonstrated that the anti-tumor efficacy of liposomal therapi...
Although liposomal accumulation at the target site is an important issue, the critical parameter de...
One of the greatest benefits of liposomal encapsulation of therapeutic drugs is the tendency for th...
Liposomes hold great potential as gene and drug delivery vehicles due to their biocompatibility and ...
One of the greatest benefits of liposomal encapsulation of therapeutic drugs is the tendency for th...
In this research the selective delivery of drug by liposomes to solid tumors as compared to healthy ...
<div><p>Various liposomal drug carriers have been developed to overcome short plasma half-life and t...
Liposomes, which are vesicles composed of a phospholipid bilayer surrounding an aqueous milieu, repr...
A previous study suggested that drug release is the dominating factor controlling biological activit...
Lately, the usefulness of liposomal drug delivery systems has been debated. To better understand the...