SummaryBackgroundStudies regarding the physiological role of acidic mammalian chitinase (AMCase) and the effects of its genetic variants on asthma have produced conflicting results.ObjectivesWe aimed to determine the genetic variants in the AMCase gene that could regulate the gene expression and thus influence disease severity.MethodsGenetic variants of the AMCase gene were determined by sequencing of asthmatics and healthy controls in up to −1 kb in the promoter region and exon 1 and 2. In an association study, a population of asthmatic (n = 504) and healthy Turkish children (n = 188) were genotyped for the observed SNPs. A replication study was performed in a North American adult population of patients with mild (n = 317) and severe (n = ...
: These authors contributed equally to this work. Abstract: Asthma is the result of chronic inflamma...
Background: Asthma exacerbations are the commonest cause of medical admissions in childhood. These h...
Background: Identifying genetic determinants for lung function is important in providing insight int...
Background: Studies regarding the physiological role of acidic mammalian chitinase (AMCase) and the ...
Background: Studies regarding the physiological role of acidic mammalian chitinase (AMCase) and the ...
SummaryBackgroundStudies regarding the physiological role of acidic mammalian chitinase (AMCase) and...
Cataloged from PDF version of article.Background: Studies regarding the physiological role of acidic...
Asthma is a disease characterized by chronic inflammation of the airway, thought to result from inap...
Background: Chitinolytic enzymes play important roles in the pathophysiology of allergic airway resp...
Background: In view of the hygiene hypothesis and the involvement of acidic mammalian chitinase (CHI...
Rationale: Few genetic studies have specifically defined the functional consequences of genetic vari...
Abstract Background Previous studies have indicated that chitinase 3-like 1 (CHI3L1) gene rs4950928 ...
Background: Even though the systemic level of SCCA1, a serine protease inhibitor, was shown to be el...
SummaryBackgroundEven though the systemic level of SCCA1, a serine protease inhibitor, was shown to ...
Astma er en alvorlig lungesykdom som antas å ramme rundt 300 millioner mennesker verden over og det ...
: These authors contributed equally to this work. Abstract: Asthma is the result of chronic inflamma...
Background: Asthma exacerbations are the commonest cause of medical admissions in childhood. These h...
Background: Identifying genetic determinants for lung function is important in providing insight int...
Background: Studies regarding the physiological role of acidic mammalian chitinase (AMCase) and the ...
Background: Studies regarding the physiological role of acidic mammalian chitinase (AMCase) and the ...
SummaryBackgroundStudies regarding the physiological role of acidic mammalian chitinase (AMCase) and...
Cataloged from PDF version of article.Background: Studies regarding the physiological role of acidic...
Asthma is a disease characterized by chronic inflammation of the airway, thought to result from inap...
Background: Chitinolytic enzymes play important roles in the pathophysiology of allergic airway resp...
Background: In view of the hygiene hypothesis and the involvement of acidic mammalian chitinase (CHI...
Rationale: Few genetic studies have specifically defined the functional consequences of genetic vari...
Abstract Background Previous studies have indicated that chitinase 3-like 1 (CHI3L1) gene rs4950928 ...
Background: Even though the systemic level of SCCA1, a serine protease inhibitor, was shown to be el...
SummaryBackgroundEven though the systemic level of SCCA1, a serine protease inhibitor, was shown to ...
Astma er en alvorlig lungesykdom som antas å ramme rundt 300 millioner mennesker verden over og det ...
: These authors contributed equally to this work. Abstract: Asthma is the result of chronic inflamma...
Background: Asthma exacerbations are the commonest cause of medical admissions in childhood. These h...
Background: Identifying genetic determinants for lung function is important in providing insight int...