Betatrophin—Promises Fading and Lessons Learned

The discovery of a potent mitogen for insulin-producing pancreatic β cells, optimistically termed “betatrophin,” excited researchers and laypeople alike, promising a new therapeutic approach to diabetes. A recent “Matters Arising” report by Gusarova and colleagues (2014) places serious doubts on whether “betatrophin” plays any major role in β cell replication