The interaction between T cell and dendritic cells (DCs) that leads to T cell activation affects the progression of the immune response including autoimmune diseases. Antigen presentation on immune cell surface, formation of an immunological synapse (IS), and specific identification of complex by T cells including two activating signals are necessary steps that lead to T cell activation. The formation of stimulatory IS involves the inclusion of costimulatory molecules, such as ICAM-1/LFA-1 and CD28/B7-1, and so on. Some fusion proteins and monoclonal antibodies targeting costimulatory molecules have been developed and approved to treat autoimmune diseases, including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), multiple scl...
It is well established that full activation of T cells requires the interaction of the TCR complex w...
AbstractIt is well established that full activation of T cells requires the interaction of the TCR c...
Fusion proteins consisting of the ligand-binding domain of CTLA4 covalently attached to an antigen (...
The interaction between T cell and dendritic cells (DCs) that leads to T cell activation affects the...
CD11b+Ly-6Chi cells, including inflammatory monocytes (IMCs) and inflammatory dendritic cells (IDCs)...
Autoimmune diseases (AID) are chronic inflammatory diseases (CID) mediated by selfreactive T and B c...
Dendritic cells (DCs) are professional antigen presenting cells displaying the unique capability to ...
In addition to their activity against intracellular pathogens, it is now clear that CD8+ T-lymphocyt...
Dendritic cells (DC) are among the first cells to encounter pathogens and damage in peripheral tissu...
This is the peer reviewed version of the following article: Manikwar, P., Kiptoo, P., Badawi, A. H.,...
CD4+ T cell interactions with dendritic cells (DC) are pivotal in adaptive immune responses and play...
Dendritic cells (DCs) are essential in inducing immunity but also in mediating immune tolerance. Alt...
This thesis describes several mechanisms in which T and B lymphocytes, together with the costimulato...
Costimulation-deficient dendritic cells (DCs) prevent autoimmune disease in mouse models. However, a...
International audienceDendritic cells (DCs) play a key role in the activation of the immune response...
It is well established that full activation of T cells requires the interaction of the TCR complex w...
AbstractIt is well established that full activation of T cells requires the interaction of the TCR c...
Fusion proteins consisting of the ligand-binding domain of CTLA4 covalently attached to an antigen (...
The interaction between T cell and dendritic cells (DCs) that leads to T cell activation affects the...
CD11b+Ly-6Chi cells, including inflammatory monocytes (IMCs) and inflammatory dendritic cells (IDCs)...
Autoimmune diseases (AID) are chronic inflammatory diseases (CID) mediated by selfreactive T and B c...
Dendritic cells (DCs) are professional antigen presenting cells displaying the unique capability to ...
In addition to their activity against intracellular pathogens, it is now clear that CD8+ T-lymphocyt...
Dendritic cells (DC) are among the first cells to encounter pathogens and damage in peripheral tissu...
This is the peer reviewed version of the following article: Manikwar, P., Kiptoo, P., Badawi, A. H.,...
CD4+ T cell interactions with dendritic cells (DC) are pivotal in adaptive immune responses and play...
Dendritic cells (DCs) are essential in inducing immunity but also in mediating immune tolerance. Alt...
This thesis describes several mechanisms in which T and B lymphocytes, together with the costimulato...
Costimulation-deficient dendritic cells (DCs) prevent autoimmune disease in mouse models. However, a...
International audienceDendritic cells (DCs) play a key role in the activation of the immune response...
It is well established that full activation of T cells requires the interaction of the TCR complex w...
AbstractIt is well established that full activation of T cells requires the interaction of the TCR c...
Fusion proteins consisting of the ligand-binding domain of CTLA4 covalently attached to an antigen (...