The human insulin-like growth factor II gene contains two development-specific promoters
- de Pagter-Holthuizen, P.
- Jansen, M.
- van Schaik, F.M.A.
- van der Kammen, R.
- Oosterwijk, C.
- Van den Brande, J.L.
- Sussenbach, J.S.
DOIAbstract
AbstractThe insulin-like growth factors (IGF) play an important role in fetal and postnatal development. Recently, the nucleotide sequences of the cDNAs encoding IGF-I and IGF-II and part of the human IGF genes were reported. In this communication we describe two distinct IGF-II cDNAs isolated from a human adult liver and a human hepatoma cDNA library, respectively. Using these two cDNAs, we have established that the human IGF-II gene contains at least 7 exons. Two different IGF-II promoters have been identified, 19 kilobases (kb) apart, which are active in a development-specific manner. The promoter, active in the adult stage, is located only 1.4 kb downstream from the insulin gene
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