Psychiatric comorbidities in patients with systemic lupus erythematosus: a systematic review of the last 10 years

AbstractObjectiveTo analyze the frequency of psychiatric comorbidities in patients with syste lupus erythematosus (SLE) using the systematic review method.MethodsA systematic literature search was performed between April and July 2011 in following databases: BIREME, PubMed and CAPES thesis database. This search priorit studies published over the last ten years (2001–2011), involving the presence of psychi comorbidities in patients with SLE.ResultsOut of 314 articles published in scientii c journals (PubMed) and 29 (BIREME), p ously identii ed ones, 13 articles on psychiatric disorders and SLE were selected so they could be submitted to the systematic review methodological approach. The articles indicated frequency of psychiatric comorbidities, especially mood and anxiety disorders. There is no consensus between the disease activity and psychiatric disorders. Patients with active showed a higher risk of developing mood disorders than patients with inactive SLE.ConclusionPatients with SLE had a higher suicide risk than the general population. M thorough studies to evaluate the psychological and genetic role, specific and non-specific autoimmune inl ammatory mechanisms in mood and anxiety disorders are needed