AbstractMatrix metalloproteinases (MMPs) cooperatively degrade all components of the extracellular matrix (ECM). Remodeling of ECM during skeletal muscle degeneration and regeneration suggests a tight regulation of matrix-degrading activity during muscle regeneration. In this study, we investigated the expression of MMP-2 and MMP-9, in normal muscles and their regulation during regeneration process. We further investigated their secretion by C2C12 myogenic cell line. Two models of muscle degeneration–regeneration were used: (1) normal muscles in which necrosis was experimentally induced by cardiotoxin injection; (2)mdxmuscles which exhibit recurrent signs of focal myofiber necrosis followed by successful regeneration. MMPs were studied by z...
Muscle cell migration and extracellular matrix remodeling are essential aspects of muscle developmen...
INTRODUCTION: Skeletal muscle has a high regenerative capacity that is maintained by the activity of...
Matrix metalloproteinases (MMPs) are secreted proteinases that have physiologic roles in degradation...
AbstractMatrix metalloproteinases (MMPs) cooperatively degrade all components of the extracellular m...
K. Hundemer University of Puget Sound, Tacoma, WA INTRODUCTION: Skeletal muscle makes up about forty...
The basal lamina of skeletal muscle is a specialized region of extracellular matrix (ECM) comprised ...
Injured skeletal muscle can undergo repair spontaneously via satellite cells activation. However, in...
The extracellular matrix (ECM) is an integral component in the structural support, force transmissio...
BACKGROUND/AIMS:Cell migration and extracellular matrix remodeling underlie normal mammalian develop...
Extracellular Matrix: Mammalian skeletal muscle is notable for both its highly ordered biophysical s...
R.E. Fitzpatrick1, G.E. McCall1, R.S. Mehan1, J. Hyatt2, J.A. Kim1 1University of Puget Sound, Tacom...
Matrix metalloproteinases (MMPs) are a group of enzymes involved in the formation and degradation of...
Extracellular Matrix: Mammalian skeletal muscle is notable for both its highly ordered biophysical s...
<div><p>Duchenne muscular dystrophy (DMD) caused by loss of cytoskeletal protein dystrophin is a dev...
Duchenne muscular dystrophy (DMD) caused by loss of cytoskeletal protein dystrophin is a devastating...
Muscle cell migration and extracellular matrix remodeling are essential aspects of muscle developmen...
INTRODUCTION: Skeletal muscle has a high regenerative capacity that is maintained by the activity of...
Matrix metalloproteinases (MMPs) are secreted proteinases that have physiologic roles in degradation...
AbstractMatrix metalloproteinases (MMPs) cooperatively degrade all components of the extracellular m...
K. Hundemer University of Puget Sound, Tacoma, WA INTRODUCTION: Skeletal muscle makes up about forty...
The basal lamina of skeletal muscle is a specialized region of extracellular matrix (ECM) comprised ...
Injured skeletal muscle can undergo repair spontaneously via satellite cells activation. However, in...
The extracellular matrix (ECM) is an integral component in the structural support, force transmissio...
BACKGROUND/AIMS:Cell migration and extracellular matrix remodeling underlie normal mammalian develop...
Extracellular Matrix: Mammalian skeletal muscle is notable for both its highly ordered biophysical s...
R.E. Fitzpatrick1, G.E. McCall1, R.S. Mehan1, J. Hyatt2, J.A. Kim1 1University of Puget Sound, Tacom...
Matrix metalloproteinases (MMPs) are a group of enzymes involved in the formation and degradation of...
Extracellular Matrix: Mammalian skeletal muscle is notable for both its highly ordered biophysical s...
<div><p>Duchenne muscular dystrophy (DMD) caused by loss of cytoskeletal protein dystrophin is a dev...
Duchenne muscular dystrophy (DMD) caused by loss of cytoskeletal protein dystrophin is a devastating...
Muscle cell migration and extracellular matrix remodeling are essential aspects of muscle developmen...
INTRODUCTION: Skeletal muscle has a high regenerative capacity that is maintained by the activity of...
Matrix metalloproteinases (MMPs) are secreted proteinases that have physiologic roles in degradation...