Application of enhanced stromal vascular fraction and fat grafting mixed with PRP in post-traumatic lower extremity ulcers

AbstractBackgroundThe authors presented their experience in regenerative surgery of post-traumatic lower extremity ulcers, evaluating the effects related to the use of Enhanced Stromal Vascular Fraction (e-SVF) and Fat Grafting with Platelet rich Plasma (PRP). The authors compared the results of two control groups.MethodThe analysis involved 20 patients aged between 23 to 62years affected by post-traumatic lower extremity ulcers. 10 patients managed with e-SVF and 10 patients managed with Fat grafting+PRP in the Plastic and Reconstructive Surgery Department at “Tor Vergata” University Rome. Patients in the first control group (n=10), were treated only with curettage and application of hyaluronic acid in the bed of ulcers. Patients in the second control group (n=10), were treated only with PRP.ResultsThe authors showed that wounds treated with e-SVF healed better than those treated with hyaluronic acid. In fact, after 9.7weeks, patients treated with e-SVF underwent 97.9%±1.5% reepithelialisation compared to 87.8%±4.4% of the first control group (only hyaluronic acid; p<0.05). Patients treated with PRP and fat grafting also showed an improvement in reepithelialisation; in fact after 9.7weeks, they underwent a 97.8%±1.5% reepithelialisation compared to 89.1%±3.8% of the second control group (only PRP; p