Parental imprinting is an epigenetic phenomenon by which genes are expressed in a monoallelic fashion, according to their parent of origin. DNA methylation is considered the hallmark mechanism regulating parental imprinting. To identify imprinted differentially methylated regions (DMRs), we compared the DNA methylation status between multiple normal and parthenogenetic human pluripotent stem cells (PSCs) by performing reduced representation bisulfite sequencing. Our analysis identified over 20 previously unknown imprinted DMRs in addition to the known DMRs. These include DMRs in loci associated with human disorders, and a class of intergenic DMRs that do not seem to be related to gene expression. Furthermore, the study showed some DMRs to b...
To access publisher's full text version of this article click on the hyperlink belowImprinting is th...
Background: Genomic imprinting is allelic restriction of gene expression potential depending on pare...
Genomic imprinting is a mechanism in which gene expression varies depending on parental origin. Impr...
Parental imprinting is an epigenetic phenomenon by which genes are expressed in a monoallelic fashio...
Background: Genomic imprinting is an important epigenetic process involved in regul...
Many imprinted genes are necessary for normal human development. Approximately 70 imprinted genes ha...
2012-09-13Among the most well-known functions of DNA methylation is in mediating imprinted gene expr...
Differential methylation between the two alleles of a gene has been observed in imprinted regions, w...
SummaryParental imprinting results in monoallelic parent-of-origin-dependent gene expression. Howeve...
The maternal and paternal copies of the genome are both required for mammalian development, and this...
Abstract Background Genes subject to genomic imprinting are mono-allelically expressed in a parent-o...
SummaryHuman pluripotent stem cells (hPSCs) are potential sources of cells for modeling disease and ...
BACKGROUND: Genes subject to genomic imprinting are mono-allelically expressed in a parent-of-origin...
Parental imprinting results in monoallelic parent-of-origin-dependent gene expression. However, many...
Large-scale transcriptome and methylome data analyses obtained by high-throughput technologies have ...
To access publisher's full text version of this article click on the hyperlink belowImprinting is th...
Background: Genomic imprinting is allelic restriction of gene expression potential depending on pare...
Genomic imprinting is a mechanism in which gene expression varies depending on parental origin. Impr...
Parental imprinting is an epigenetic phenomenon by which genes are expressed in a monoallelic fashio...
Background: Genomic imprinting is an important epigenetic process involved in regul...
Many imprinted genes are necessary for normal human development. Approximately 70 imprinted genes ha...
2012-09-13Among the most well-known functions of DNA methylation is in mediating imprinted gene expr...
Differential methylation between the two alleles of a gene has been observed in imprinted regions, w...
SummaryParental imprinting results in monoallelic parent-of-origin-dependent gene expression. Howeve...
The maternal and paternal copies of the genome are both required for mammalian development, and this...
Abstract Background Genes subject to genomic imprinting are mono-allelically expressed in a parent-o...
SummaryHuman pluripotent stem cells (hPSCs) are potential sources of cells for modeling disease and ...
BACKGROUND: Genes subject to genomic imprinting are mono-allelically expressed in a parent-of-origin...
Parental imprinting results in monoallelic parent-of-origin-dependent gene expression. However, many...
Large-scale transcriptome and methylome data analyses obtained by high-throughput technologies have ...
To access publisher's full text version of this article click on the hyperlink belowImprinting is th...
Background: Genomic imprinting is allelic restriction of gene expression potential depending on pare...
Genomic imprinting is a mechanism in which gene expression varies depending on parental origin. Impr...