p25/Cdk5 dysregulation may contribute to neurodegeneration. In this issue of Neuron, Kim et al. show that cdk5 inactivates HDAC-1, leading to cell cycle deregulation and DNA damage accumulation. This study provides further insights into the function of p25/Cdk5 in neurons and points to HDAC-1 as a target for therapeutic interventions
Cyclin-dependent kinase 5 (Cdk5) is a serine–threonine kinase with remarkably diverse functions. Alt...
The cyclin-dependent kinase cdk5 is atypically active in postmitotic neurons and enigmatic among the...
While the requirement of CDKs in cell cycle control is well established, the participation of CDK fa...
p25/Cdk5 dysregulation may contribute to neurodegeneration. In this issue of Neuron, Kim et al. show...
Aberrant cell-cycle activity and DNA damage are emerging as important pathological components in var...
SummaryAberrant cell-cycle activity and DNA damage are emerging as important pathological components...
Aberrant cell-cycle activity and DNA damage are emerging as important pathological components in var...
In a variety of neurodegenerative disease, despite the frequent correlation of neuronal cell cycle a...
Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine (ser)/threonine (Thr) kinase that has ...
Hippocampal sclerosis (HS) is the most common cause of chronic medically refractory epilepsy in adul...
There is increasing evidence suggesting that cyclin-dependent kinases (Cdks) that normally regulate ...
Since the identification of cyclin-dependent kinase-5 (Cdk5) as a tau kinase and member of the Cdk f...
Alzheimer\u27s disease (AD) is the most common neurological disorder, but no current therapies succe...
Elevated activity of the Cdk5/p25 complex has been implicated in the pathogenesis of Alzheimer's dis...
The purpose of this literature research project is to investigate the role of Cyclin- dependent kina...
Cyclin-dependent kinase 5 (Cdk5) is a serine–threonine kinase with remarkably diverse functions. Alt...
The cyclin-dependent kinase cdk5 is atypically active in postmitotic neurons and enigmatic among the...
While the requirement of CDKs in cell cycle control is well established, the participation of CDK fa...
p25/Cdk5 dysregulation may contribute to neurodegeneration. In this issue of Neuron, Kim et al. show...
Aberrant cell-cycle activity and DNA damage are emerging as important pathological components in var...
SummaryAberrant cell-cycle activity and DNA damage are emerging as important pathological components...
Aberrant cell-cycle activity and DNA damage are emerging as important pathological components in var...
In a variety of neurodegenerative disease, despite the frequent correlation of neuronal cell cycle a...
Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine (ser)/threonine (Thr) kinase that has ...
Hippocampal sclerosis (HS) is the most common cause of chronic medically refractory epilepsy in adul...
There is increasing evidence suggesting that cyclin-dependent kinases (Cdks) that normally regulate ...
Since the identification of cyclin-dependent kinase-5 (Cdk5) as a tau kinase and member of the Cdk f...
Alzheimer\u27s disease (AD) is the most common neurological disorder, but no current therapies succe...
Elevated activity of the Cdk5/p25 complex has been implicated in the pathogenesis of Alzheimer's dis...
The purpose of this literature research project is to investigate the role of Cyclin- dependent kina...
Cyclin-dependent kinase 5 (Cdk5) is a serine–threonine kinase with remarkably diverse functions. Alt...
The cyclin-dependent kinase cdk5 is atypically active in postmitotic neurons and enigmatic among the...
While the requirement of CDKs in cell cycle control is well established, the participation of CDK fa...
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