AbstractDespite recent advances in precision medicine, many molecular-based antineoplastic agents do not potentiate sustainable long term remissions, warranting the investigation of novel therapeutic strategies. Heat shock protein 90 (Hsp90) is a molecular chaperone that not only has oncogenic properties, but also has distinct expression profiles in malignant and normal cells, providing a rational strategy to attain preferential damage. Prior attempts to target Hsp90 with natural product-based compounds have been hampered by their associated off target toxicities, suggesting that novel, fully synthetic inhibitors may be required to achieve the specificity necessary for therapeutic efficacy. Therefore, this review highlights the antineoplast...
Resistance to current treatments of cancer encourages finding new therapeutical targets. The heat sh...
Heat shock protein 90 (Hsp90) is a conserved and constitutively expressed molecular chaperone and it...
PU-H71, a Heat shock protein 90 (Hsp90) inhibitor, has yielded therapeutic efficacy in many preclini...
The molecular chaperone heat shock protein 90 (Hsp90) is involved in the maturation and stabilizatio...
AbstractAgents that inhibit Hsp90 function hold significant promise in cancer therapy. Here we prese...
AbstractSince initial discovery of the first HSP90 inhibitor over a decade and a half ago, tremendou...
AbstractAgents that inhibit Hsp90 function hold significant promise in cancer therapy. Here we prese...
Over the past decade, heat-shock protein (HSP)90 has begun to draw increasing attention as a novel a...
The molecular chaperone heat shock protein 90 (HSP90) is essential for the folding stability, intrac...
The molecular chaperone heat shock protein 90 (HSP90) is essential for the folding stability, intrac...
The molecular chaperone heat shock protein 90 (HSP90) is essential for the folding stability, intrac...
The last decade has seen the molecular chaperone heat shock protein 90 (HSP90) emerge as an exciting...
PU-H71 is a purine-scaffold Hsp90 inhibitor developed to overcome limitations of conventional Hsp90 ...
Cancer chemotherapy is often compromised by development of multidrug resistance (MDR). Numerous stra...
The molecular chaperone heat shock protein 90 (HSP90) is essential for the folding stability, intrac...
Resistance to current treatments of cancer encourages finding new therapeutical targets. The heat sh...
Heat shock protein 90 (Hsp90) is a conserved and constitutively expressed molecular chaperone and it...
PU-H71, a Heat shock protein 90 (Hsp90) inhibitor, has yielded therapeutic efficacy in many preclini...
The molecular chaperone heat shock protein 90 (Hsp90) is involved in the maturation and stabilizatio...
AbstractAgents that inhibit Hsp90 function hold significant promise in cancer therapy. Here we prese...
AbstractSince initial discovery of the first HSP90 inhibitor over a decade and a half ago, tremendou...
AbstractAgents that inhibit Hsp90 function hold significant promise in cancer therapy. Here we prese...
Over the past decade, heat-shock protein (HSP)90 has begun to draw increasing attention as a novel a...
The molecular chaperone heat shock protein 90 (HSP90) is essential for the folding stability, intrac...
The molecular chaperone heat shock protein 90 (HSP90) is essential for the folding stability, intrac...
The molecular chaperone heat shock protein 90 (HSP90) is essential for the folding stability, intrac...
The last decade has seen the molecular chaperone heat shock protein 90 (HSP90) emerge as an exciting...
PU-H71 is a purine-scaffold Hsp90 inhibitor developed to overcome limitations of conventional Hsp90 ...
Cancer chemotherapy is often compromised by development of multidrug resistance (MDR). Numerous stra...
The molecular chaperone heat shock protein 90 (HSP90) is essential for the folding stability, intrac...
Resistance to current treatments of cancer encourages finding new therapeutical targets. The heat sh...
Heat shock protein 90 (Hsp90) is a conserved and constitutively expressed molecular chaperone and it...
PU-H71, a Heat shock protein 90 (Hsp90) inhibitor, has yielded therapeutic efficacy in many preclini...