AbstractIn this issue of Chemistry & Biology, a novel Aldol-Switch mechanism is proposed for the biosynthesis of type III polyketides, which include many antioxidants found in colorful fruits [1]. Based on structural and mutagenesis studies, the Aldol-Switch mechanism suggests that electronic effects balance between two competing cyclization specificities in Type III polyketide synthases. A novel hypothesis is also used to explain stilbenecarboxylate biosynthesis
Two hallmarks of assembly line polyketide synthases have motivated an interest in these unusual mult...
Polyketides are important bioactive natural products biosynthesized by bacteria, fungi, and plants. ...
169 p.Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2009.The polyketides are a diverse...
AbstractStilbene synthase (STS) and chalcone synthase (CHS) each catalyze the formation of a tetrake...
Complex polyketides comprise a large number of natural products that have broad application in medic...
Natural products continue to inspire scientists on the search for biological active structures. Rece...
Natural products are a well-established source of drugs, and evolution has yielded polyketides such ...
Polyketide synthases catalyze the assembly of complex natural products from simple precursors such a...
sem informação4217183Natural products continue to inspire scientists on the search for biological ac...
Resorcylic acid lactones and dihydroxyphenylacetic acid lactones represent important pharmacophores ...
International audiencePolyketides are a fascinating class of natural products with highly diverse, o...
Polyketides are structurally and functionally diverse secondary metabolites that are biosynthesized ...
Polyketide synthases (PKSs) are remarkable enzymes. The diverse products from naturally ocurring PK...
Polyketides are a diverse class of medically important natural products whose biosynthesis is cataly...
AbstractBackground: Polyketide synthases (PKSs) generate molecular diversity by utilizing different ...
Two hallmarks of assembly line polyketide synthases have motivated an interest in these unusual mult...
Polyketides are important bioactive natural products biosynthesized by bacteria, fungi, and plants. ...
169 p.Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2009.The polyketides are a diverse...
AbstractStilbene synthase (STS) and chalcone synthase (CHS) each catalyze the formation of a tetrake...
Complex polyketides comprise a large number of natural products that have broad application in medic...
Natural products continue to inspire scientists on the search for biological active structures. Rece...
Natural products are a well-established source of drugs, and evolution has yielded polyketides such ...
Polyketide synthases catalyze the assembly of complex natural products from simple precursors such a...
sem informação4217183Natural products continue to inspire scientists on the search for biological ac...
Resorcylic acid lactones and dihydroxyphenylacetic acid lactones represent important pharmacophores ...
International audiencePolyketides are a fascinating class of natural products with highly diverse, o...
Polyketides are structurally and functionally diverse secondary metabolites that are biosynthesized ...
Polyketide synthases (PKSs) are remarkable enzymes. The diverse products from naturally ocurring PK...
Polyketides are a diverse class of medically important natural products whose biosynthesis is cataly...
AbstractBackground: Polyketide synthases (PKSs) generate molecular diversity by utilizing different ...
Two hallmarks of assembly line polyketide synthases have motivated an interest in these unusual mult...
Polyketides are important bioactive natural products biosynthesized by bacteria, fungi, and plants. ...
169 p.Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2009.The polyketides are a diverse...
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