In this issue of Structure, de Leon-Boenig and colleagues bring to light several key characteristics of NF-κB inducing kinase (NIK), which is at the center of many pathological disorders, using an impressive body of structural and functional studies. Structures of NIK described here provide deep insights into the mechanism of NIK activity regulation and may facilitate the design of new generation inhibitors for therapeutic use
Summary: Canonical NF-κB signaling is constitutively activated in acute myeloid leukemia (AML) stem ...
Successful kinase inhibitor drug discovery relies heavily on the structural knowledge of the interac...
NF-κB inducing kinase (NIK, also known as MAP3K14) is a serine/threonine protein-kinase that is cruc...
In this issue of Structure, de Leon-Boenig and colleagues bring to light several key characteristics...
SummaryThe NF-κB inducing kinase (NIK) regulates the non-canonical NF-κB pathway downstream of impor...
NF-κB-inducing kinase (NIK) is a key player in non-canonical NF-κB signaling, involved in several fu...
As a wide variety of pro-inflammatory cytokines are involved in the development of rheumatoid arthri...
NF-κB-inducing kinase (NIK) is a protein kinase central to the noncanonical NF-κB pathway downstream...
We report here structure-guided optimization of a novel series of NF-κB inducing kinase (NIK) inhibi...
The cellular kinases inhibitory-κB kinase (IKK) α and Nuclear Factor-κB (NF-&kappa...
NF-κB inducing kinase (NIK), which is considered as the central component of the non-canonical NF-κB...
In this work, we aimed to build a 3D-model of NIK and to study the binding of pyrazolo[4,3-c]isoquin...
As a wide variety of pro-inflammatory cytokines are involved in the development of rheumatoid arthri...
'This is the author's version of a work that was accepted for publication in Journal of Structural B...
The NFκB signaling pathway is a central regulator of inflammatory and immune responses in virtually ...
Summary: Canonical NF-κB signaling is constitutively activated in acute myeloid leukemia (AML) stem ...
Successful kinase inhibitor drug discovery relies heavily on the structural knowledge of the interac...
NF-κB inducing kinase (NIK, also known as MAP3K14) is a serine/threonine protein-kinase that is cruc...
In this issue of Structure, de Leon-Boenig and colleagues bring to light several key characteristics...
SummaryThe NF-κB inducing kinase (NIK) regulates the non-canonical NF-κB pathway downstream of impor...
NF-κB-inducing kinase (NIK) is a key player in non-canonical NF-κB signaling, involved in several fu...
As a wide variety of pro-inflammatory cytokines are involved in the development of rheumatoid arthri...
NF-κB-inducing kinase (NIK) is a protein kinase central to the noncanonical NF-κB pathway downstream...
We report here structure-guided optimization of a novel series of NF-κB inducing kinase (NIK) inhibi...
The cellular kinases inhibitory-κB kinase (IKK) α and Nuclear Factor-κB (NF-&kappa...
NF-κB inducing kinase (NIK), which is considered as the central component of the non-canonical NF-κB...
In this work, we aimed to build a 3D-model of NIK and to study the binding of pyrazolo[4,3-c]isoquin...
As a wide variety of pro-inflammatory cytokines are involved in the development of rheumatoid arthri...
'This is the author's version of a work that was accepted for publication in Journal of Structural B...
The NFκB signaling pathway is a central regulator of inflammatory and immune responses in virtually ...
Summary: Canonical NF-κB signaling is constitutively activated in acute myeloid leukemia (AML) stem ...
Successful kinase inhibitor drug discovery relies heavily on the structural knowledge of the interac...
NF-κB inducing kinase (NIK, also known as MAP3K14) is a serine/threonine protein-kinase that is cruc...
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