Excitement and controversy followed the discovery that a frequently occurring single nucleotide polymorphism in noncoding DNA affects cancer susceptibility. In this issue of Cancer Cell, Post et al. (2010) report using a mouse model to demonstrate directly that this subtle genetic variation significantly attenuates the p53 pathway and accelerates tumor formation
SummaryThe ability of p53 to regulate transcription is crucial for tumor suppression and implies tha...
The single nucleotide polymorphism (SNP) at codon 72 of the tumor suppressor gene p53 codes for eith...
International audienceSingle-nucleotide variants (SNVs) are the most frequent genetic changes found ...
Cancer biology finds itself in a post-genomic era and the hopes of using inherited genetic variants ...
Commonly inherited genetic variants, such as single nucleotide polymorphisms (SNPs) hold great promi...
The p53 pathway constitutes a major cellular gene network that is crucial in directing the suppressi...
In a recent article, a candidate pathway approach was taken to try to identify single nucleotide pol...
Decades of research have shown that mutations in the p53 stress response pathway affect the incidenc...
Single nucleotide polymorphisms (SNPs) are germline variations interspersed in the human genome. The...
Heterogeneity is a pervasive concept in oncology and underpins many of the biggest challenges facing...
Predisposition to non-familial, sporadic cancer is strongly influenced by multiple tumor susceptibil...
Single nucleotide polymorphisms (SNPs) are germline variations interspersed in the human genome. The...
AbstractThe tumor suppressor p53 gene is mutated in minimally half of all cancers. It is therefore r...
Decades of research have shown that mutations in the p53 stress response pathway affect the incidenc...
The tumor suppressor p53 gene is mutated in minimally half of all cancers. It is therefore reasonabl...
SummaryThe ability of p53 to regulate transcription is crucial for tumor suppression and implies tha...
The single nucleotide polymorphism (SNP) at codon 72 of the tumor suppressor gene p53 codes for eith...
International audienceSingle-nucleotide variants (SNVs) are the most frequent genetic changes found ...
Cancer biology finds itself in a post-genomic era and the hopes of using inherited genetic variants ...
Commonly inherited genetic variants, such as single nucleotide polymorphisms (SNPs) hold great promi...
The p53 pathway constitutes a major cellular gene network that is crucial in directing the suppressi...
In a recent article, a candidate pathway approach was taken to try to identify single nucleotide pol...
Decades of research have shown that mutations in the p53 stress response pathway affect the incidenc...
Single nucleotide polymorphisms (SNPs) are germline variations interspersed in the human genome. The...
Heterogeneity is a pervasive concept in oncology and underpins many of the biggest challenges facing...
Predisposition to non-familial, sporadic cancer is strongly influenced by multiple tumor susceptibil...
Single nucleotide polymorphisms (SNPs) are germline variations interspersed in the human genome. The...
AbstractThe tumor suppressor p53 gene is mutated in minimally half of all cancers. It is therefore r...
Decades of research have shown that mutations in the p53 stress response pathway affect the incidenc...
The tumor suppressor p53 gene is mutated in minimally half of all cancers. It is therefore reasonabl...
SummaryThe ability of p53 to regulate transcription is crucial for tumor suppression and implies tha...
The single nucleotide polymorphism (SNP) at codon 72 of the tumor suppressor gene p53 codes for eith...
International audienceSingle-nucleotide variants (SNVs) are the most frequent genetic changes found ...
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