The genomic organization of chromatin is increasingly recognized as a key regulator of cell behavior, but deciphering its regulation mechanisms requires detailed knowledge of chromatin's primary structure—the assembly of nucleosomes throughout the genome. This Primer explains the principles for mapping and analyzing the primary organization of chromatin on a genomic scale. After introducing chromatin organization and its impact on gene regulation and human health, we then describe methods that detect nucleosome positioning and occupancy levels using chromatin immunoprecipitation in combination with deep sequencing (ChIP-Seq), a strategy that is now straightforward and cost efficient. We then explore current strategies for converting the seq...
This thesis presents a broad study of the chromatin structure and function with special focus in the...
Every cell in the human body contains the identical hereditary information, encoded in the DNA. The ...
Every cell in the human body contains the identical hereditary information, encoded in the DNA. The ...
The genomic organization of chromatin is increasingly recognized as a key regulator of cell behavior...
Beyond linear sequence, higher order structure of the genome influences gene regulation and has been...
<p>Chromatin structure plays an important role in gene regulation, especially in differentiating the...
The epigenetic regulation of gene transcription underlies the diversity between species and within o...
The genome of a eukaryotic cell is stored inside the nucleus in a highly condensed form called chrom...
AbstractEukaryotic genomes, which comprise as many as 3 billion DNA bases, are packaged into a highe...
Nucleosomes are the basic packaging units of chromatin, modulating accessibility of regulatory prote...
Nucleosome is the fundamental building block of eukaryotic chromatin. The precise location of nucleo...
The hierarchical organization of chromatin is known to associate with diverse cellular functions; ho...
Large-scale chromatin compaction varies across the human genome, and these variations correlate with...
The genetic architecture of complex traits is multifactorial. Genome-wide association studies (GWASs...
Every cell in the human body contains the identical hereditary information, encoded in the DNA. The ...
This thesis presents a broad study of the chromatin structure and function with special focus in the...
Every cell in the human body contains the identical hereditary information, encoded in the DNA. The ...
Every cell in the human body contains the identical hereditary information, encoded in the DNA. The ...
The genomic organization of chromatin is increasingly recognized as a key regulator of cell behavior...
Beyond linear sequence, higher order structure of the genome influences gene regulation and has been...
<p>Chromatin structure plays an important role in gene regulation, especially in differentiating the...
The epigenetic regulation of gene transcription underlies the diversity between species and within o...
The genome of a eukaryotic cell is stored inside the nucleus in a highly condensed form called chrom...
AbstractEukaryotic genomes, which comprise as many as 3 billion DNA bases, are packaged into a highe...
Nucleosomes are the basic packaging units of chromatin, modulating accessibility of regulatory prote...
Nucleosome is the fundamental building block of eukaryotic chromatin. The precise location of nucleo...
The hierarchical organization of chromatin is known to associate with diverse cellular functions; ho...
Large-scale chromatin compaction varies across the human genome, and these variations correlate with...
The genetic architecture of complex traits is multifactorial. Genome-wide association studies (GWASs...
Every cell in the human body contains the identical hereditary information, encoded in the DNA. The ...
This thesis presents a broad study of the chromatin structure and function with special focus in the...
Every cell in the human body contains the identical hereditary information, encoded in the DNA. The ...
Every cell in the human body contains the identical hereditary information, encoded in the DNA. The ...