AbstractMassive investment and technological advances in the collection of extensive and longitudinal information on thousands of Alzheimer patients results in large amounts of data. These “big-data” databases can potentially advance CNS research and drug development. However, although necessary, they are not sufficient, and we posit that they must be matched with analytical methods that go beyond retrospective data-driven associations with various clinical phenotypes. Although these empirically derived associations can generate novel and useful hypotheses, they need to be organically integrated in a quantitative understanding of the pathology that can be actionable for drug discovery and development. We argue that mechanism-based modeling ...
Epidemiological projections of the prevalence of Alzheimer's disease (AD) and related dementias, the...
International audienceDespite the acceleration of knowledge and data accumulation in neuroscience ov...
We seek a Pitt Momentum Teaming Grant to support the data extraction, analysis, and planning needed ...
AbstractMassive investment and technological advances in the collection of extensive and longitudina...
AbstractMany disease-modifying clinical development programs in Alzheimer's disease (AD) have failed...
The "big data" paradigm has gained a lot of attention recently, in particular in those areas of biom...
Neurodegenerative diseases such as Alzheimer's disease (AD) follow a slowly progressing dysfunctiona...
Big Data: could it ever cure Alzheimer’s disease? When, with the benefit of hindsight, people look b...
Developing drugs for treating Alzheimer’s disease (AD) has been extremely challenging and costly due...
Dementia remains an extremely prevalent syndrome among older people and represents a major cause of ...
Dementia remains an extremely prevalent syndrome among older people and represents a major cause of ...
Alzheimer's disease is the most common form of dementia that affects 50 million people worldwide (Wo...
Decades of experimental and clinical research have contributed to unraveling many mechanisms in the ...
Alzheimer's disease (AD) is a devastating neurodegenerative disorder affecting millions of people wo...
Dementia is a symptom of many neurodegenerative disorders that have a heavy economic burden. In this...
Epidemiological projections of the prevalence of Alzheimer's disease (AD) and related dementias, the...
International audienceDespite the acceleration of knowledge and data accumulation in neuroscience ov...
We seek a Pitt Momentum Teaming Grant to support the data extraction, analysis, and planning needed ...
AbstractMassive investment and technological advances in the collection of extensive and longitudina...
AbstractMany disease-modifying clinical development programs in Alzheimer's disease (AD) have failed...
The "big data" paradigm has gained a lot of attention recently, in particular in those areas of biom...
Neurodegenerative diseases such as Alzheimer's disease (AD) follow a slowly progressing dysfunctiona...
Big Data: could it ever cure Alzheimer’s disease? When, with the benefit of hindsight, people look b...
Developing drugs for treating Alzheimer’s disease (AD) has been extremely challenging and costly due...
Dementia remains an extremely prevalent syndrome among older people and represents a major cause of ...
Dementia remains an extremely prevalent syndrome among older people and represents a major cause of ...
Alzheimer's disease is the most common form of dementia that affects 50 million people worldwide (Wo...
Decades of experimental and clinical research have contributed to unraveling many mechanisms in the ...
Alzheimer's disease (AD) is a devastating neurodegenerative disorder affecting millions of people wo...
Dementia is a symptom of many neurodegenerative disorders that have a heavy economic burden. In this...
Epidemiological projections of the prevalence of Alzheimer's disease (AD) and related dementias, the...
International audienceDespite the acceleration of knowledge and data accumulation in neuroscience ov...
We seek a Pitt Momentum Teaming Grant to support the data extraction, analysis, and planning needed ...