The epidermal growth factor receptor (EGFR) is normally activated by ligand-induced dimerization. Oncogenic mutations in EGFR promote activation in a largely ligand-independent manner. Shan et al. uncover a partially disordered state of EGFR kinase, providing evidence that oncogenic mutations counteract this intrinsic structural instability to promote dimerization and aberrant activation
Aberrant activation of the epidermal growth factor receptor (EGFR) by mutations has been implicated ...
Aberrant activation of the epidermal growth factor receptor (EGFR) by mutations has been implicated ...
Aberrant activation of the epidermal growth factor receptor (EGFR) by mutations has been implicated ...
The epidermal growth factor receptor (EGFR) plays vital roles in cellular processes including cell p...
SummaryThe mutation and overexpression of the epidermal growth factor receptor (EGFR) are associated...
Epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that is commonly activated by ...
SummaryThe epidermal growth factor receptor (EGFR) plays pivotal roles in development and is mutated...
Epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that is commonly activated by ...
Aberrant activation of the epidermal growth factor receptor (EGFR) by mutations has been implicated ...
Aberrant activation of the epidermal growth factor receptor (EGFR) by mutations has been implicated ...
Aberrant activation of the epidermal growth factor receptor (EGFR) by mutations has been implicated ...
Aberrant activation of the epidermal growth factor receptor (EGFR) by mutations has been implicated ...
The epidermal growth factor receptor (EGFR) plays pivotal roles in development and is mutated or ove...
Aberrant activation of the epidermal growth factor receptor (EGFR) by mutations has been implicated ...
Aberrant activation of the epidermal growth factor receptor (EGFR) by mutations has been implicated ...
Aberrant activation of the epidermal growth factor receptor (EGFR) by mutations has been implicated ...
Aberrant activation of the epidermal growth factor receptor (EGFR) by mutations has been implicated ...
Aberrant activation of the epidermal growth factor receptor (EGFR) by mutations has been implicated ...
The epidermal growth factor receptor (EGFR) plays vital roles in cellular processes including cell p...
SummaryThe mutation and overexpression of the epidermal growth factor receptor (EGFR) are associated...
Epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that is commonly activated by ...
SummaryThe epidermal growth factor receptor (EGFR) plays pivotal roles in development and is mutated...
Epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that is commonly activated by ...
Aberrant activation of the epidermal growth factor receptor (EGFR) by mutations has been implicated ...
Aberrant activation of the epidermal growth factor receptor (EGFR) by mutations has been implicated ...
Aberrant activation of the epidermal growth factor receptor (EGFR) by mutations has been implicated ...
Aberrant activation of the epidermal growth factor receptor (EGFR) by mutations has been implicated ...
The epidermal growth factor receptor (EGFR) plays pivotal roles in development and is mutated or ove...
Aberrant activation of the epidermal growth factor receptor (EGFR) by mutations has been implicated ...
Aberrant activation of the epidermal growth factor receptor (EGFR) by mutations has been implicated ...
Aberrant activation of the epidermal growth factor receptor (EGFR) by mutations has been implicated ...
Aberrant activation of the epidermal growth factor receptor (EGFR) by mutations has been implicated ...
Aberrant activation of the epidermal growth factor receptor (EGFR) by mutations has been implicated ...