Calmodulin Lobotomized Novel Insights into Calcium Regulation of Voltage-Gated Calcium Channels

AbstractCalcium entry via voltage-gated calcium channels can be regulated by calcium- and voltage-dependent inactivation mechanisms. For years, only L-type channels were thought to be capable of calcium-dependent inactivation (CDI). In this issue of Neuron, Liang et al. present evidence to show that CDI is a much more widely applicable feedback mechanism that limits calcium entry in response to rising intracellular calcium