Influence of HIV-associated degree of immune suppression on molecular heterogeneity of hepatitis B virus among HIV co-infected patients
- Pal, Ananya
- Panigrahi, Rajesh
- Biswas, Avik
- Datta, Sibnarayan
- Sarkar, Neelakshi
- Guha, Subhashish Kamal
- Saha, Bibhuti
- Banerjee, Arup
- Chakrabarti, Sekhar
- Chakravarty, Runu
DOIAbstract
AbstractWe have investigated the molecular diversity of Hepatitis B virus (HBV) among the HIV co-infected patients from eastern-India. HBsAg/HBV-DNA positive subjects (n=73) from 874 HIV-infected patients were analyzed by sequencing followed by genetic diversity quantification. HBV/genotype-D and HBV/sugenotype-D2 were predominant. HBV/D2 isolates from patients with low CD4 count manifested significantly lower non-synonymous substitutions (p<0.0001) and Shannon entropy (p=0.0006) in their surface and polymerase gene in comparison to those from moderately increased CD4 count. ART-induced immune-reconstitution therefore might raise non-synonymous immune/therapy escape substitutions among these HBV/D2 isolates. Decreased genetic diversity and ...
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