AbstractAscorbic acid (Vitamin C) has a critical role in bone formation and osteoblast differentiation, but very little is known about the molecular mechanisms of ascorbic acid entry into bone marrow stromal cells (BMSCs). To address this gap in knowledge, we investigated the identity of the transport system that is responsible for the uptake of ascorbic acid into bone marrow stromal cells (BMSCs). First, we examined the expression of the two known isoforms of the sodium-coupled ascorbic acid transporter, namely SVCT1 and SVCT2, in BMSCs (Lin−ve Sca1+ve) and bone at the mRNA level. Only SVCT2 mRNA was detected in BMSCs and bone. Uptake of ascorbic acid in BMSCs was Na+-dependent and saturable. In order to define the role of SVCT2 in BMSC di...
in skeletal muscle, vitamin C not only enhances carnitine biosynthesis but also protects cells again...
Ascorbic acid (AA), the reduced form of vitamin C, is transported within many cell types through hig...
Two sodium-dependent vitamin C transporter isoforms (SVCT1 and SVCT2) were identified as ascorbic ac...
AbstractAscorbic acid (Vitamin C) has a critical role in bone formation and osteoblast differentiati...
AbstractVitamin C is an antioxidant that plays a vital role in various biological processes includin...
© 2015. Vitamin C is an antioxidant that plays a vital role in various biological processes includin...
AbstractBone marrow stromal cell (BMSC) adhesion and migration are fundamental to a number of pathop...
Bone marrow stromal cell (BMSC) adhesion and migration are fundamental to a number of pathophysiolog...
Vitamin C is accumulated in mammalian cells by two types of proteins: sodium-ascorbate co-transporte...
AbstractCollagen II is the major protein component of articular cartilage and forms the collagen fib...
Vitamin C is essential for many enzymatic reactions and also acts as a free radical scavenger. Speci...
A number of studies have revealed that Type I diabetes (T1D) is associated with bone loss and an inc...
Vitamin C (ascorbic acid) is required for the synthesis of collagen, carnitine, catecholamine and th...
AbstractWe report here on the cloning and functional characterization of human Na+-dependent vitamin...
Ascorbate plays a vital role as a co-factor for a superfamily of enzymes, the 2-oxoglutarate depende...
in skeletal muscle, vitamin C not only enhances carnitine biosynthesis but also protects cells again...
Ascorbic acid (AA), the reduced form of vitamin C, is transported within many cell types through hig...
Two sodium-dependent vitamin C transporter isoforms (SVCT1 and SVCT2) were identified as ascorbic ac...
AbstractAscorbic acid (Vitamin C) has a critical role in bone formation and osteoblast differentiati...
AbstractVitamin C is an antioxidant that plays a vital role in various biological processes includin...
© 2015. Vitamin C is an antioxidant that plays a vital role in various biological processes includin...
AbstractBone marrow stromal cell (BMSC) adhesion and migration are fundamental to a number of pathop...
Bone marrow stromal cell (BMSC) adhesion and migration are fundamental to a number of pathophysiolog...
Vitamin C is accumulated in mammalian cells by two types of proteins: sodium-ascorbate co-transporte...
AbstractCollagen II is the major protein component of articular cartilage and forms the collagen fib...
Vitamin C is essential for many enzymatic reactions and also acts as a free radical scavenger. Speci...
A number of studies have revealed that Type I diabetes (T1D) is associated with bone loss and an inc...
Vitamin C (ascorbic acid) is required for the synthesis of collagen, carnitine, catecholamine and th...
AbstractWe report here on the cloning and functional characterization of human Na+-dependent vitamin...
Ascorbate plays a vital role as a co-factor for a superfamily of enzymes, the 2-oxoglutarate depende...
in skeletal muscle, vitamin C not only enhances carnitine biosynthesis but also protects cells again...
Ascorbic acid (AA), the reduced form of vitamin C, is transported within many cell types through hig...
Two sodium-dependent vitamin C transporter isoforms (SVCT1 and SVCT2) were identified as ascorbic ac...