La localisation microsomale de la synthese des acides gras dans le foie de la souris vivante

AbstractMice were given glucose-U-14C and the radioactivity of triglyceride and phospholipid glycerol and fatty acids was measured 30 sec, 3 or 30 min after the i.v. administration in liver microsomes and supernatant. After the acetate administration the radioactivity of palmitic and stearic acids and that of their carboxyl carbons was also measured. The repartition of the radioactivity was discussed in relation with the localization of fatty acid synthesis. In agreement with our previous results it was suggested that the endoplasmic reticulum is the main site of this synthesis